Objective To evaluate the efficacy of glaucoma drainage device（GDD）compared to trabeculectomy（Trab）in the treatment of patients with glaucoma.Methods Cochrane evaluation Methodology was used to evaluate the literature of randomized controlled trail（RCT）of comparing glaucoma drainage device with trabeculectomy for glaucoma.As controlling intraocular pressure（IOP）

the baseline IOP before the operation and end-point IOP after the operation were collected to calculate the intraocular pressure ratio（IOPR%）.And the mean difference（MD）was used as effect factors to analyze the efficacy to control IOP.1year after the operation comparing the success rate of reaching the target IOP with or without anti-glaucoma medicine and the relative risk（RR）were used as effect factors.Results A total of 351 eyes from 351 patients were studied in this meta-analysis.172 eyes of GDD group received GDD among which 113 eyes received EX-PRESS and 59 eyes received Ahmed glaucoma valve implant;179eyes received Trab as the Trab group.There was no significant difference between IOP% of 2groups in controlling the IOP（MD=-0.59

95%CI=-7.48

6

.29

P=0.87）.1year after the operation the success rate of GDD group reaching the target IOP（5 mmHg

<

IOP

<

18mmHg

1mmHg=0.133kPa）without anti-glaucoma was higher than the Trab group and the difference was significant（RR=1.55

95%CI=1.21

1

.99

P=0.000 6）.1year after the operation the success rate of GDD group reaching the target IOP（5 mmHg

<

IOP

<

18 mmHg）with anti-glaucoma was higher than the Trab group and the difference was significant（RR=1.11

95%CI=1.03

1

.20

P=0.008）.Conclusion In the treatment of glaucoma the efficacy of GDD and Trab are similar while in controlling the IOP the success rate of GDD is higher than the Trab.