Objective To observe the effects of different doses of aspirin and clopidogrel for the function pf platelet aggregation on patients with coronary heart disease and aspirin resistance（AR）.Method 90 cases of patients with coronary artery disease and AR were screened

randomly divided into three groups and respectively given oral aspirin 100 mg

300mg and clopidogrel 75 mg plus aspirin100 mg.After four weeks

the rates of platelet aggregation were tested with the whole blood resistance method.Results The rates of platelet aggregation in groups treated with aspirin 100 mg and 300 mg had no significant difference

but the rate of platelet aggregation in the group given aspirin plus clopidogrel was significantly lower（P<0.05）.ConclusionAR in patients with coronary artery disease can not be significantly improved by increasing the dose of aspirin

but aspirin plus clopidogrel can effectively inhibit platelet aggregation and reduce the incidence of AR.Clinical observation and nursing intervention for AR patients should be strengthened.