Gastric cancer is one of the most common malignant tumors in the world

which can be treated mainly through surgery

chemotherapy and radiotherapy

but the clinical effects are not satisfactory.At present

the targeted therapy for gastric cancer is still not ideal.Single targeted therapy tends to cause resistance and tumor recurrence

and multi-target combination therapy will be a development trend for targeted therapy of gastric cancer molecules.This paper introduces hepatocyte growth factor（HGF）/hepatocyte growth factor receptor（c-Met）signal transduction pathway in occurrence

development and invasion and metastasis of gastric cancer

which is a potential target for treating gastric cancer.A large number of drugs target for this pathway in recent researches and progresses have been made in clinical research

but researchers face many challenges due to different races and subtypes of gastric cancer.Conducting further research on mechanism of HGF/c-Met signal transduction pathway and selecting gastric cancer patients with unique molecular subtype through multiple channels for conducting targeted clinical test can provide new ideas for treating gastric cancer.