Objective To explore the clinical value of cisplatin（DDP）

5-Fluorouracil（5-FU）

pingyangmycin（PYM） combined with tetrahydrofolate（CF） and concurrent radiochemotherapy in treating mid-term and terminal oral squamous cell carcinoma.Method 90 mid-term and terminal oral squamous patients were divided into group A and group B randomly

with 50 patients in each group

among which group A adopted the therapeutic plan of DFP（DDP+5-FU+PYM）chemotherapy+ concurrent radiochemotherapy

group B adopted the plan of DFP combined with CF chemotherapy+ concurrent radiochemotherapy.Result The response rate（RR） of group A and B were 80%、93.3% respectively

and the differences were significant（p<0.05）.Major adverse reactions were local chromatosis

white blood cell decrease and oral mucositis etc.There were more toxic reactions in group B than in group A.Conclusion Therapeutic plan of DFP combined with CF chemotherapy+ concurrent radiochemotherapy to treat mid-term and terminal oral squamous cell carcinoma can effectively control local tumors

have satisfactory short-term curative effect

few adverse reactions

less treatment cost

and can be spread as the first choice of treating oral cancer.