Objective To study the therapeutic effect of neurasthenia in undergraduate students. Method 80 undergraduate students of neurasthenia were treated with the combination therapy including psychotherapy

sports-treatment and medication for two months

and then the therapeutic effect was judged according to the Symptom Checklist 90 （SCL-90） before and after treatment. Results The total score of SCL-90 before and after treatment were（195.14±51.98） and （160.21±13.14） with significant difference（t=11.35

P<0.01）. After treatment the total positive score

the average score of positive and the number of plsitive items all improved markedly and the difference had statistical significance（P<0.01）. The number of complete recovery

marked improvement

improvement and treatment resistance cases were 36 （45.00%）

24 （30.00%）

16 （20.00%） and 4 （5.00%）

respectively.Conclusions The combination therapy would be more effective than monotherapy and worthwhile for application.