It remains a common problem that the evaluation model of course learning for stu-dents is so simple in the higher education of China. Moreover， the teachers are usually used to evalu-ating student's course learning by summative appraisal and ignore process appraisal， so that the stu-dents are usually lack of learning enthusiasm for self study. Besides， the course learning evaluation of students generally lacks the uniform and detail standard in the country. To resolve these problems， a comprehensive evaluation model of course learning based on the principle of talent evaluation has been practiced and improved since 2007 in some basic medical courses at our university. This model is composed of four parts： the evaluation of mastering basic knowledge， the evaluation of the ability to resolve problems through applied knowledge， the evaluation of practical study and the evaluation of learning initiatives. The model has showed in the practice the characteristics of powerful operability， pluralistic evaluating indicators， combining summative appraisal and process one， reflecting objectively the mastering degree of expertise of students and promoting the self-study of students.