Objective　To evaluate the assessment index system of internal medicine， and to analyze the factors of practical effects on internal medicine. Methods　The assessment index system of clinical skills was developed by expert group based on the clinical syllabus and objectives. Internal medicine index system was divided into four items such as history-taking， physical examination， hos-pital records and case questions. 49 five-year clinical interns who took internal medicine exams were researched. Reliability， validity， discrimination， difficulty were used to analyze the quality of assess-ment index system. Gender， teaching hospital and the preparation of postgraduate examination were used to explore the influencing factors of practical effects with independent t-test and Wilcoxon signed rank tests. Results　The reliability， discrimination， difficulty of the assessment index system were 0.50， 0.15 and 0.85， respectively. The removing item coefficient of history collection， physical ex-amination， hospital records， case questions were 0.38， 0.26， 0.47 and 0.53， separately， and the discrimination were 0.18， 0.17，0.27 and 0.37， separately， and the difficulty were 0.87， 0.89， 0.79， and 0.78， respectively. The scores of assessment index system of girls were higher than those of the boys（P<0.05）. Moreover， the girls scored higher in history collection and physical examination， compared with the boys（P<0.05）. The discrepancy scores were not statistically significant among teaching hospitals（P >0.05）. The students who prepared the postgraduate examination scored lower than the others（P<0.05）. Conclusions　The assessment index system of internal medicine is reason-able and reliable

but the assessment of case questions still needs to be standardized. Teaching hospi-tals have little effect on internship while gender and the preparation for postgraduate examination influence practice effects in internal medicine.