A rat model of liver cirrhosis was produced by long term intra-peritoneal injections of D-galactosamine (GalN) prepared in our lab. Seven experimental rats were given GalN 250 mg/Kg/day 6 days per week for 153-216 days

another seven rats served as control.The predominant findings in the experimental rats consisted of enlargement and overweight of the liver with yellowish grey tinge and diffuse granular nodules on its surface. The edge of the liver was uneven and its consistency hard. No changes in the contour and weight of the kidney

lung

heart and spleen were

found. The findings of the liver under light microscope were: mild cirrhosis in 1

moderate in 3

and severe in 3. Other organs examined were normal. Biochemical examinations revealed an abncrmal A/G ratio and mAO value conforming with the cirrhotic change. The specificity of GalN-induced cirrhosis rat model was confirmed.Our experience in the study was briefly discussed.