EFFECTS OF SODIUM RESTRICTION ON THE ANGIOTENSIN FACILITATION OF NORADRENERGIC NEUROTRANSMISSION IN CENTRAL TISSUES OF THE RAT

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EFFECTS OF SODIUM RESTRICTION ON THE ANGIOTENSIN FACILITATION OF NORADRENERGIC NEUROTRANSMISSION IN CENTRAL TISSUES OF THE RAT

更新时间：2024-01-17

- EFFECTS OF SODIUM RESTRICTION ON THE ANGIOTENSIN FACILITATION OF NORADRENERGIC NEUROTRANSMISSION IN CENTRAL TISSUES OF THE RAT
- Journal of Chongqing Medical University Issue 3, Pages: 165-170(1985)
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- Published：1985，
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[1]М.J.Мeldrum,,,,,,,,,薛春生,,,,,,,,,L.Вadino,,,,,,,,,Т.С.Westfall.低钠对血管紧张素促进大鼠中枢组织中肾上腺素能传递的影响[J].重庆医学院学报,1985(03):165-170.

EFFECTS OF SODIUM RESTRICTION ON THE ANGIOTENSIN FACILITATION OF NORADRENERGIC NEUROTRANSMISSION IN CENTRAL TISSUES OF THE RAT. [J]. Journal of Chongqing Medical University (3):165-170(1985)
[1]М.J.Мeldrum,,,,,,,,,薛春生,,,,,,,,,L.Вadino,,,,,,,,,Т.С.Westfall.低钠对血管紧张素促进大鼠中枢组织中肾上腺素能传递的影响[J].重庆医学院学报,1985(03):165-170. DOI：

EFFECTS OF SODIUM RESTRICTION ON THE ANGIOTENSIN FACILITATION OF NORADRENERGIC NEUROTRANSMISSION IN CENTRAL TISSUES OF THE RAT. [J]. Journal of Chongqing Medical University (3):165-170(1985) DOI：

摘要

本文用正常和限制钠大鼠研究了血管紧张素Ⅱ（AngⅡ）促进刺激所致

H-去甲肾上腺素（

H-NE）从中枢两个心血管调节区释放的作用。AngⅡ(10

-7

M)促进

H-NE从Sprague-Dawley和Wistar大鼠的孤束核A

区释放

但不促进从前下丘脑释放。用限钠饲料喂养大鼠

则阻滞AngⅡ促进

H-NE释放的作用。同时给予Captopril和低钠饲料

可部分恢复AngⅡ的促进作用。慢性静脉输注AngⅡ

与限制钠引起同样的对AngⅡ促进

H-NE释放作用的阻滞。这些结果表明

低钠饲料能通过与肾素-血管紧张素系统相互作用而改变AngⅡ促进

H-NE释放的作用。

Abstract

This study investigated the ability of angiotensin I (Ang I) to facilitate the stimulation induced release of 3H-norepinephrin (3H-NE) from two cardiovascular regulatory areas in normal and sodium restricted rats. Ang I (10~7M) facilitated the stimulation induced release of 3H-NE from the A2 area of the nucleus tractus solita-rius but not from the anterior hypothalamus of Sprague-Dawley and Wistar rats. Placement of rats on a sodium restricted diet blocked the facilitation of 3H-NE release due to Ang I . Captopril given with the sodium restricted diet partially restored the facilitory effect of Ang I . Chronic I V Ang II infusions blocked the facilitory effect of Ang II on 3H-NE release in a manner similar to that seen with sodium restriction. These results suggest that low sodium diets may alter the facilitation of 3H-NE release by Ang I by interactions with the renin-angiotensin system.

关键词

孤束核前下丘脑低钠血管紧张素Captopril肾上腺素能传递

Keywords

Nucleus tractus solitariusAnterior hypothalamusLow sodiumAngiotensinCaptoprilAdrenergic neurotransmission

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THE EFFECT OF SODIUM DEPLETION ON THE FACILITORY EFFECT OF ANGIOTENSIN ON ADRENERGIC NEUROTRANSMISSION IN THE RAT PORTAL VEIN

Related Author

薛春生

Т.C.Wcstfall

М.J.Мeldrum

L.Вadino

Related Institution

重庆医学院药理教研室

Department

Department of Pharmacology

.Louis University

.S.A

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