Effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia

FU Zhongxue; et al

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Effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia

更新时间：2024-01-17

- Effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia
- Journal of Chongqing Medical University Issue 3, Pages: 260-263(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 德国科隆大学医学院第二外科
  3. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R656
- Published：2002，
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[1]傅仲学,Nagelschmidt Manfred,Holthausen Ulla,Troidl Hans,张才全,韩文妙.CO_2气腹对内毒素血症猪的代谢影响[J].重庆医科大学学报,2002(03):260-263.

FU Zhongxue, et al. Effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia. [J]. Journal of Chongqing Medical University (3):260-263(2002)
[1]傅仲学,Nagelschmidt Manfred,Holthausen Ulla,Troidl Hans,张才全,韩文妙.CO_2气腹对内毒素血症猪的代谢影响[J].重庆医科大学学报,2002(03):260-263. DOI：

FU Zhongxue, et al. Effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia. [J]. Journal of Chongqing Medical University (3):260-263(2002) DOI：

摘要

目的:探讨CO2气腹对内毒素血症猪代谢的影响。方法:只雄性家猪随机分为对照组;内毒素组和内毒素加二氧21化碳气腹组。实验在静吸复合麻醉下进行。组和组经静脉给予内毒素

后组用BC30minCCO2建立气腹。每监测一次各60min种指标和收集标本。气腹持续。3h结果:CO2气腹组动脉血呈显著的混合型酸中毒改变

导致了值和值显著降低apHipH（P<;0.05）CO2气腹组肠壁水平明显低于对照组和内毒素组

但无显著性差异;ATPCO2气腹对内毒素引起的α代谢变化无TNF-明显影响。结论:本研究提示在有基础生理紊乱

即使是亚临床的生理紊乱的情况下

CO2气腹可能导致严重的酸碱平衡紊乱、组织酸中毒和能量代谢紊乱。

Abstract

Objective: To investigate the effects of pneumoperitoneum with carbon dioxide on metabolism in pigs with endotoxemia. Methods: Twenty-one pigs randomly divided into three groups: control group(group A)

endotoxin group (group B

2μg/kg·h)

endotoxin and pneumoperitoneum with CO2 group (group C

15mmHg). The experimental period of the study was 5.5 hours ( 30 min endotoxemia

3 hours pneumoperitoneum

2 hours further monitor). Primary endpoints were arterial blood gas

mucosal pH of jejunum(ipH) and ATP level of jejunum wall. Statistical evaluation was performed by analysis of ANOVA Student-Newman-Keuls. Results: Endotoxin infusion can induce symptoms of an early septic shock. Two animals in group C died in 1~2 hours after pneumoperitoneum with CO2 due to serious acidosis and shock. Pneumoperitoneum with CO2 led to significant decrease of apH

ipH

aHCO3 - and aBE and significant increase of aPCO2. Endotoxin may induce significant increase of plasma TNF-α

but there was no difference between group B and group C. ATP level of jejunum wall in group C was lower than that of group A and group B

but there was no significant diffrence in all of the three groups. Conclusion: Our study suggests that pneumoperitoneum with carbon dioxide during endotoxemia can seriously damage the acid-base balance and metabolism of energy of experimental animal. We think laparoscopic operation with pneumoperitoneum with CO2 can enhance the risk of patients with sepsis.

关键词

气腹二氧化碳内毒素血症

Keywords

pneumoperitoneumCarbon dioxideendotoxemia

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