The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa

WU Xiaoling; et al

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The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa

更新时间：2024-01-17

- The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa
- Journal of Chongqing Medical University Issue 3, Pages: 257-259(2002)
- 作者机构：
  
  1. 重庆医科大学第二临床学院内科
  2. 重庆医科大学第二临床学院内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.2
- Published：2002，
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[1]吴小翎,冯志松.胃粘膜癌变过程中Fas、FasL的表达及意义[J].重庆医科大学学报,2002(03):257-259+263.

WU Xiaoling, et al. The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. [J]. Journal of Chongqing Medical University (3):257-259(2002)
[1]吴小翎,冯志松.胃粘膜癌变过程中Fas、FasL的表达及意义[J].重庆医科大学学报,2002(03):257-259+263. DOI：

WU Xiaoling, et al. The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. [J]. Journal of Chongqing Medical University (3):257-259(2002) DOI：

摘要

目的:通过检测胃粘膜癌变过程中凋亡相关蛋白、的表达

探讨其在胃癌发生发展中的作用。FasFasL方法:采用免疫组化法检测例慢性浅表性胃炎（）、例慢性萎缩性胃炎伴肠化生（）、例异型增生（）和例SP41CSG19CAGIM22Dys37胃癌（）。GC结果:在、、和组中的阳性表达率依次下降

的阳性表达率则逐渐升高;、FasCSGCAGIMDysGCFasLFasFasL在高中分化组的阳性表达率均显著高于低分化组。GCGC结论:、的阳性表达率在胃癌发生过程中呈现不同的变化趋FasFasL势

提示由诱导的胃粘膜细胞凋亡异常与胃癌形成可能有密切关系。在胃癌患者

与癌细胞分化有关的、表Fas/FasLFasFasL达的一致性有助于判断肿瘤的恶性程度和预后。

Abstract

Objective: To investigate the expression and significance of Fas

Fas ligand in carcinogenesis of gastric mucosa. Methods: SP immunohistochemistry. Results: The expression rate of Fas in chronic superficial gastritis group was significantly higher than that of dysplasia and gastric cancer groups (P<0.05). The expression rate of Fas ligand in chronic superficial gastritis group was significantly lower than that of other groups ( P<0.05). In the patients with gastric cancer

the expression rates of Fas and Fas ligand were correlated with the degree of differentiation. Conclusion: The abnormal expression of Fas and Fas ligand in carcinogenesis of gastric mucosa may be involved in the pathogenesis and differentiation of gastric cancer.

关键词

胃癌癌前病变FasFas Ligand

Keywords

gastric cancerPrecancerous lesionFasFas ligand

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Related Institution

Department of Gastrointestinal Surgery，The Third Affiliated Hospital of Zunyi Medical University/ The First People’s Hospital of Zunyi

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The Sixth Ward，Department of General Surgery， The First Hospital of Lanzhou University

Department of Gastroenterology,the Third People’s Hospital of Chongqing

Teaching and Research Section of Pathology,College of Basic Medicine,Molecular Medicine and Cancer Research Center,Chongqing Medical University

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