Cathepsin B expression and its relationship with microvessel density and biological behaviour in colorectal cancer

LIN Xiao; et al

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Cathepsin B expression and its relationship with microvessel density and biological behaviour in colorectal cancer

更新时间：2024-01-17

- Cathepsin B expression and its relationship with microvessel density and biological behaviour in colorectal cancer
- Journal of Chongqing Medical University Issue 3, Pages: 264-266(2002)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理教研室
  2. 重庆医科大学基础医学院病理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.34
- Published：2002，
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[1]林晓,王娅兰.大肠癌组织蛋白酶B表达及其与肿瘤微血管密度和生物学行为的关系[J].重庆医科大学学报,2002(03):264-266+270.

LIN Xiao, et al. Cathepsin B expression and its relationship with microvessel density and biological behaviour in colorectal cancer. [J]. Journal of Chongqing Medical University (3):264-266(2002)
[1]林晓,王娅兰.大肠癌组织蛋白酶B表达及其与肿瘤微血管密度和生物学行为的关系[J].重庆医科大学学报,2002(03):264-266+270. DOI：

LIN Xiao, et al. Cathepsin B expression and its relationship with microvessel density and biological behaviour in colorectal cancer. [J]. Journal of Chongqing Medical University (3):264-266(2002) DOI：

摘要

目的:探讨不同类型大肠癌组织蛋白酶（）表达及其与肿瘤微血管密度（BCathepsinB

CBmicrovesseldensity

）和生物学行为的关系。MVD方法:采用免疫组化方法对例不同类型大肠癌及进行半定量和定量研究。47CBMVD结果:CB在大肠癌粘液性癌表达高于非粘液性癌

差别具显著性（P<）

强阳性组值高于阴性组

二者具有显著差异0.05CBMVD（P<）。大肠癌表达与淋巴结转移关系密切（0.05CBP<）。0.05结论:结果提示

大肠癌表达与值和肿瘤浸润转CBMVD移有关

在粘液性大肠癌浸润转移中作用可能更为重要。CB

Abstract

Objective: To discuss cathepsin B(CB) expression in colorectal cancer and its relationship with microvessel density (MVD) and biological behaviour. Methods: CB and MVD was detected by method of immunohistochemistry with ration and half-ration in 47 cases of colorectal cancer. Results: The prevalence of CB positive in mucinous colorectal carcinoma was significantly higher than that in non-mucinous colorectal carcinoma. There were also significant differences between mucinous colorectal carcinoma and non-mucinus colorectal cacinoma(P<0.05). The quantity of MVD in the group with CB strong positive was greater than that in the group with CB negative . There were also significant differences between them ( P<0.05). Conclusion: The results suggest that CB expression has corelation with MVD

invasion and metastasis in colorectal carcinoma. CB may be more important in the invasion and metastasis of mucinous colorectal carcinoma .

关键词

大肠癌组织蛋白酶B浸润转移血管生成免疫组织化学

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