The effect of hepatocyte growth factor(HGF) on graft mucosal cell proliferation and apoptosis after rat small bowel transplantation

LI Kezhou; et al

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The effect of hepatocyte growth factor(HGF) on graft mucosal cell proliferation and apoptosis after rat small bowel transplantation

更新时间：2024-01-17

- The effect of hepatocyte growth factor(HGF) on graft mucosal cell proliferation and apoptosis after rat small bowel transplantation
- Journal of Chongqing Medical University Issue 4, Pages: 388-390(2002)
- 作者机构：
  
  1. 成都军区总医院普外科,重庆医科大学临床学院普外科,南京军区总医院普通外科,南京军区总医院普通外科,成都,610083
  2. ,重庆,400016
  3. 210002,南京,南京,210002
- 作者简介：
- 基金信息：
- DOI：
  CLC： R656.7
- Published：2002，
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[1]李可洲,杜成友,黎介寿,李宁.HGF对大鼠移植小肠粘膜细胞增殖及凋亡的作用研究[J].重庆医科大学学报,2002(04):388-390.

LI Kezhou, et al. The effect of hepatocyte growth factor(HGF) on graft mucosal cell proliferation and apoptosis after rat small bowel transplantation. [J]. Journal of Chongqing Medical University (4):388-390(2002)
[1]李可洲,杜成友,黎介寿,李宁.HGF对大鼠移植小肠粘膜细胞增殖及凋亡的作用研究[J].重庆医科大学学报,2002(04):388-390. DOI：

LI Kezhou, et al. The effect of hepatocyte growth factor(HGF) on graft mucosal cell proliferation and apoptosis after rat small bowel transplantation. [J]. Journal of Chongqing Medical University (4):388-390(2002) DOI：

摘要

目的：了解肝细胞生长因子（HGF）对大鼠移植小肠粘膜细胞增殖及凋亡状态的影响。方法：Wistar（RT1k ）大鼠行异位全小肠移植后第2天开始给予肠外营养至第10天，对照组（n=10）行常规TPN支持，HGF组（n=10）行常规TPN支持并加HGF，采用流式细胞技术及原位末端标记技术观察各组实验前后移植肠粘膜细胞增殖指数的变化。结果：两组移植前基准增殖指数及凋亡指数无显著差异（P>0.05），实验后对照组移植肠粘膜细胞增殖指数较移植前明显下降，HGF组增殖指数较移植前明显升高，对照组凋亡指数较移植前明显升高，HGF组凋亡指数增加不明显。结论：HGF能明显促进大鼠移植小肠粘膜细胞增殖，并减轻其凋亡，构成了其对移植肠形态及功能维护作用的物质基础。

Abstract

Objective: To study the effect of hepatocyte growth factor(HGF) on mucosal cell of small bowel isograft. Methods: Total small bowel transplantation was made with inbred Wistar(RT1k) rats heterotopically

either total patenteral nutrition(TPN group

n=10) or hepatocyte growth factor supplemented TPN(HGF group

n=10) was used in recipients from POD2 to POD10. Proliferative index and apoptotic index were studied. Results: There were no apparent difference between proliferative index and apoptotic index in two groups before small bowel transplantation(SBT); PI decreased greatly and AI increased significantly in TPN group after SBT. There were no significant change in both PI and AI in HGF group after transplantation. Conclusion:Hepatocyte growth factor (HGF) can significantly enhance mucosal cell proliferation and inhibit cell apoptosis of isotransplanted small bowel graft.

关键词

肝细胞生长因子移植完全胃肠外营养增殖凋亡

Keywords

hepatocyte growth factortransplantationTotal parenteral nutritionproliferationapoptosis

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