An experimental study of TGF-beta receptor expression in kidney of diabetic rats

XIAO Qian; et al

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An experimental study of TGF-beta receptor expression in kidney of diabetic rats

更新时间：2024-01-17

- An experimental study of TGF-beta receptor expression in kidney of diabetic rats
- Journal of Chongqing Medical University Issue 4, Pages: 391-393(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科
  2. 重庆医科大学临床学院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.2
- Published：2002，
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[1]肖谦,汪恕萍.糖尿病大鼠肾脏TGF-β受体蛋白表达的实验研究[J].重庆医科大学学报,2002(04):391-393.

XIAO Qian, et al. An experimental study of TGF-beta receptor expression in kidney of diabetic rats. [J]. Journal of Chongqing Medical University (4):391-393(2002)
[1]肖谦,汪恕萍.糖尿病大鼠肾脏TGF-β受体蛋白表达的实验研究[J].重庆医科大学学报,2002(04):391-393. DOI：

XIAO Qian, et al. An experimental study of TGF-beta receptor expression in kidney of diabetic rats. [J]. Journal of Chongqing Medical University (4):391-393(2002) DOI：

摘要

目的：探讨持续高血糖对糖尿病大鼠肾脏转化生长因子βⅠ型受体（TGFβRⅠ）和转化生长因子βII型受体（TGFβRII）蛋白表达的影响。方法：雄性Wistar大鼠20只随机分为正常对照组（C组）和糖尿病组（D组），实验第9周用免疫组化和图像分析系统检测两组肾脏TGFβRI和TGFβRII蛋白表达水平。结果：与对照组相比，糖尿病组TGFβRI和TGFβII蛋白表达分别增加100%和118%（P<0.01）。结论：持续高血糖显著增加糖尿病大鼠肾脏TGFβRI和TGFβRII受体蛋白表达，可能对糖尿病肾病的发生发展发挥重要作用。

Abstract

Objective: To investigate the influence of sustained hyperglycemia on protein expression of transforming growth factorβtype I receptor (TGFβRI) and transforming growth factorβtype II receptor (TGFβRII) in kidney of diabetic rats. Methods: 20 male Wistar rats were randomly divided into two groups: control group (group C) and streptozotozin-induced diabetic rats (group D). The rats of two groups were used to study protein expression of TGFβRI and TGFβRII with immunohistochemistry and image analysis at 9 weeks. Results: Compared with group C

the protein expression of TGFβRI and TGFβRII in group D had increased by 100% and 118%

respectively. Conclusion: Sustained hyperglycemia can significantly increase protein expression of TGFβRI and TGFβRII in kidney of diabetic rats. It may play an important role in the progression of diabetic nephropathy.

关键词

糖尿病肾病转化生长因子-βI型受体转化生长因子-βII型受体

Keywords

diabetic nephropathyTransforming growth factor-βtype I receptorTransforming growth factor-βtype II receptor

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