Investigation of the risk factors of diabetic nephropathy in type 2 diabetes

LIU Dongfang; et al

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Investigation of the risk factors of diabetic nephropathy in type 2 diabetes

更新时间：2024-01-17

- Investigation of the risk factors of diabetic nephropathy in type 2 diabetes
- Journal of Chongqing Medical University Issue 3, Pages: 298-300(2002)
- 作者机构：
  
  1. 重庆医科大学第二临床学院内分泌科
  2. 重庆医科大学第二临床学院内分泌科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2002，
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[1]刘东方,庞久高,严钟德,吴玲,李荣.2型糖尿病患者糖尿病肾病危险因素分析[J].重庆医科大学学报,2002(03):298-300+303.

LIU Dongfang, et al. Investigation of the risk factors of diabetic nephropathy in type 2 diabetes. [J]. Journal of Chongqing Medical University (3):298-300(2002)
[1]刘东方,庞久高,严钟德,吴玲,李荣.2型糖尿病患者糖尿病肾病危险因素分析[J].重庆医科大学学报,2002(03):298-300+303. DOI：

LIU Dongfang, et al. Investigation of the risk factors of diabetic nephropathy in type 2 diabetes. [J]. Journal of Chongqing Medical University (3):298-300(2002) DOI：

摘要

目的:探讨大样本的型糖尿病患者糖尿病肾病的危险因素

为糖尿病肾病的临床防治工作提供参考意见。2方法:问卷式调查糖尿病病程、高血压家族史

测定糖尿病患者动态血压、心率功率谱、24hHbA1、血、血脂及尿白蛋白排泄cNO率（）等

将糖尿病患者分为糖尿病对照组和糖尿病肾病组

比较两组间各因素的差异

分析各因素与的关系。UAERUAER结果:糖尿病肾病组平均血压、病程、高血压家族史、胆固醇（）较糖尿病对照组显著增加

及自主神经功能24hTCNO（

）显著低于对照组（PHVPVVP<）

且血压、病程、、、、均与密切相关0.05NOPHVPVVTCUAER（P<;多元逐0.05）步回归分析显示血压、病程、自主神经功能是作用于的主要因素。UAER结论:糖尿病肾病是长期代谢紊乱、血压升高和血液流变学异常、自主神经病变及遗传易感等多因素作用的结果

其中

病程长、血压升高、伴有自主神经病变的患者更易出现糖尿病肾脏损害

因此应早期采取综合性的防治措施。

Abstract

Objective: To study the correlated risk factors about diabetic nephropathy of type 2 diabetes. Methods:、 To investigate diabetes durationfamily hypertention history with questionnaire

determine the 24-hour ambulatory blood pressure

heart rate power spectrum

HbA1c

serum nitric oxide(NO)

plasma lipids and urinary albumin excretionrate (UAER). The patients were divided into diabetic control group and diabetic nephropathy group. To compare the difference among these factors between the two groups and analyze the relationship of these factors and UAER. Results:、、 The 24-hour mean blood pressurediabetes duration family hypertention history

total cholesterol in diabetic nephropathy group were significantly higher than diabetic control group. NO and autonomic nerve function were lower than that of diabetic control. Furthermore

these factors were correlated with UAER. Conclusion: Diabetic nephropathy is the result of multiple factors

such as metabolic disorder

blood pressure elevation

abnormal hemorheology

genetic factor etc

among these blood pressure

diabetes duration and autonomic neuropathy are the main factors to impact on UAER

so the comprehensive prevention actions should be taken to diabetic nephropathy.

关键词

2型糖尿病糖尿病肾病危险因素

Keywords

type 2 diabetesdiabetic nephropathyrisk factor

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