The perioperative application of prostaglandin E<sub>1</sub> for patients with rheumatic heart diease associated with pulmonary hypertension

LI Xiaoconget al

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The perioperative application of prostaglandin E₁ for patients with rheumatic heart diease associated with pulmonary hypertension

更新时间：2024-01-17

- The perioperative application of prostaglandin E₁ for patients with rheumatic heart diease associated with pulmonary hypertension
- Journal of Chongqing Medical University Issue 3, Pages: 295-297(2002)
- 作者机构：
  
  1. 重庆医科大学临床学院胸心外科
  2. 重庆医科大学临床学院胸心外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R654.2
- Published：2002，
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[1]李小丛,李朝先,向小勇,蒋迎久,黄阳礼.前列腺素E_1在风湿性心脏病并肺动脉高压围手术期应用[J].重庆医科大学学报,2002(03):295-297.

LI Xiaoconget al. The perioperative application of prostaglandin E₁ for patients with rheumatic heart diease associated with pulmonary hypertension. [J]. Journal of Chongqing Medical University (3):295-297(2002)
[1]李小丛,李朝先,向小勇,蒋迎久,黄阳礼.前列腺素E_1在风湿性心脏病并肺动脉高压围手术期应用[J].重庆医科大学学报,2002(03):295-297. DOI：

LI Xiaoconget al. The perioperative application of prostaglandin E₁ for patients with rheumatic heart diease associated with pulmonary hypertension. [J]. Journal of Chongqing Medical University (3):295-297(2002) DOI：

摘要

目的:观察前列腺素E1（PGE1）在风湿性心脏病风心病并肺动脉高压围手术期中对血液动力学、术后并发症和（）生存率的影响。方法:回顾性对照分析研究例风心病并肺动脉高压患者在我院行瓣膜置换术病人。组例（年月225A10819921～年月）;组例（年月～年月）

组术前静脉给小剂量前列腺素19971B1171997120006BE1（PGE1

～10ng/kg/min20ng/kg/）

术前周;术后同样用法周。其它治疗方案同组。min100g/d21A结果:PGE1具有选择性降低肺动脉压

改善心功能

减少术后并发症

提高术后生存率等作用。结论:PGE1在风心病并肺动脉高压围手术期中具有较理想的药理效果和临床作用。

Abstract

Objective: To observe perioperative hemodynamics and postoperative deaths and complications after prostaglandin E1 (PGE1) administration in patients with rheumatic heart diease associated with pulmonary hypertension. Methods: The 225 valve replacement cases with rheumatic heart disease associated with pulmonary hypertension were collected and analyzed retrospectively. Those cases were divided into two groups: in group A there were 108 cases between Jan 1992 and Jan 1997

in group B there were 117 cases beween Jan 1997 and Jun 2000. To group B

continuous intravenous drip of small dose PGE1 was given at a speed between 10 ng/kg/min and 20 ng/kg/min

100μg daily for two weeks before cardiac surgery

the same way for one week after cardiac surgery

the other treatment was the same as group A. Results: Small dose PGE1 not only can decrease pulmonary artery pressure significantly

but also improve cardiac function and decrease postoperative complications and deaths. Conclusion: PGE1 could play important role in the perioperative valve replacement of rheumatic heart diease associated with pulmonary hypertension.

关键词

前列腺素E1风湿性心脏病肺动脉高压

Keywords

Prostaglandin E1rheumatic heart diseasepulmonary hypertension

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JIANG Yingjiu

Zhang Qingqing

Related Institution

Department of Cardiac-thoracic Surgery,College of Clinical Medicine,Chongqing Medical Universty

Research Center for High Altitude Medicine， Qinghai University；Key Laboratory of High Altitude Medicine， Ministry of Education；Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province

Department of Anesthesiology,The First Affiliated Hospital of Chongqing Medical University

Department of Anesthesiology,the Children’s Hospital,Chongqing Medical University

Department of Internal Medicine,the Military Hospital

⁰

The perioperative application of prostaglandin E1 for patients with rheumatic heart diease associated with pulmonary hypertension

DOI：

摘要

Abstract

关键词

Keywords

references

The perioperative application of prostaglandin E₁ for patients with rheumatic heart diease associated with pulmonary hypertension