Expression and clinical significance of muti-drug resistance factors:P-gp,GST-π,TOPOП in lung cancer

PENG Le; et al

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Expression and clinical significance of muti-drug resistance factors:P-gp,GST-π,TOPOП in lung cancer

更新时间：2024-01-17

- Expression and clinical significance of muti-drug resistance factors:P-gp,GST-π,TOPOП in lung cancer
- Journal of Chongqing Medical University Issue 3, Pages: 384-387(2006)
- 作者机构：
  
  1. 重庆医科大学
  2. 重庆医科大学附属第二医院心胸外科七年制
  3. ,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2
- Published：2006，
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[1]彭乐,江跃全.耐药表型P-gp,GST-π,及TOPOⅡ的表达与Ki67在肺癌中的表达及其临床意义[J].重庆医科大学学报,2006(03):384-387.

PENG Le, et al. Expression and clinical significance of muti-drug resistance factors:P-gp,GST-π,TOPOП in lung cancer. [J]. Journal of Chongqing Medical University (3):384-387(2006)
[1]彭乐,江跃全.耐药表型P-gp,GST-π,及TOPOⅡ的表达与Ki67在肺癌中的表达及其临床意义[J].重庆医科大学学报,2006(03):384-387. DOI：

PENG Le, et al. Expression and clinical significance of muti-drug resistance factors:P-gp,GST-π,TOPOП in lung cancer. [J]. Journal of Chongqing Medical University (3):384-387(2006) DOI：

摘要

目的:检测P-gp

GST-π

TOPOП与Ki67在肺癌中的表达

探讨其在肺癌中的表达水平及其临床相关性。方法:用免疫组化方法检测52例术前未进行化疗的肺癌组织中P-gp

GST-π

TOPOП与Ki67的表达。结果:P-gp

GST-π

TOPOП和Ki67在肺癌中的阳性表达率分别是73%

80.5%

62.5%

23.7%.P-gp

GST-π的表达与病理组织学分型

分化程度有显著相关性（P<0.05）;TOPOП在腺癌中的表达明显低于其他类型的肺癌（P<0.05）;P-gp

GST-π

TOPOП的共表达率明显高于其单一表达率（P<0.05）;P-gp

GST-π

TOPOП的表达与Ki67之间无显著相关性。结论:P-gp

GST-π

TOPOП在不同类型的肺癌中均可表达

且表达水平不同

但它们均与肺癌的耐药相关

且呈共同表达

所以以上指标可以作为临床判断预后和指导化疗的综合指标。

Abstract

Objective: To examine the expression of P-gp

GST-π

TOPOП and Ki67 in lung cancer and study the clinical relationship of P-gp

GST-π

TOPOПand Ki67 Co-expression in lung cancer.Methods: The expression of P-gp

GST-π

TOPOП in 52 cases of lung cancer without chemotherapy was detected before operation by immunohistochemical staning.Results: The positive rates of P-gp

GST-π

TOPOП

Ki67 were respectively 73%

80.5%

62.5%

23.7%.The P-gp

GST-π expression was correlated with the histology and differentiation

The expression of TOPOП was obviously lower in adenocarcinoma than in other typers of lung cancers;The coexpression rate of more than one MDR gene production appareatly exceeded individual expression rate.The expression of P-gp

GST-π

TOPOП was not correlated with the expression of Ki67.Conclusion: P-gp

GST-π

TOPOП can be expressed in different types of lung cancers and with different expression levels

They are all correlated with multidrug resistance of lung cancer

Thus

they can be regarded as a valuable indicators for clinical chemotherapy and for prognosis in lung cancer patients.

关键词

肺癌多药耐药免疫组化

Keywords

lung cancerMDRimmunohistochemistry

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