Survivin expression in ovarian cancer and its associationwith tumor cellular apoptosis

SHU Wen; et al

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Survivin expression in ovarian cancer and its associationwith tumor cellular apoptosis

更新时间：2024-01-17

- Survivin expression in ovarian cancer and its associationwith tumor cellular apoptosis
- Journal of Chongqing Medical University Issue 3, Pages: 388-390(2006)
- 作者机构：
  
  1. 重庆医科大学附属第二医院妇产科
  2. 四川大学华西第二医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.31
- Published：2006，
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[1]舒文,胡丽娜.Survivin的表达与卵巢癌细胞凋亡的关系[J].重庆医科大学学报,2006(03):388-390.

SHU Wen, et al. Survivin expression in ovarian cancer and its associationwith tumor cellular apoptosis. [J]. Journal of Chongqing Medical University (3):388-390(2006)
[1]舒文,胡丽娜.Survivin的表达与卵巢癌细胞凋亡的关系[J].重庆医科大学学报,2006(03):388-390. DOI：

SHU Wen, et al. Survivin expression in ovarian cancer and its associationwith tumor cellular apoptosis. [J]. Journal of Chongqing Medical University (3):388-390(2006) DOI：

摘要

目的:探讨卵巢癌凋亡抑制基因Survivin的表达、细胞凋亡关系及临床意义。方法:用末端脱氧核糖核酸转移酶介导的TUNEL法和免疫组织化学技术检测50例卵巢癌组织原位凋亡（AI）、Survivin的表达。结果:50例卵巢癌组织中Survivin阳性表达率72%（36/50）

其表达与AI相关。Survivin阴性表达组的5年生存率显著高于阳性表达组（P<0.05）;Cox模型多因素分析表明

高AI（≥1.7%）患者累积生存率较高（P<0.05）。结论:凋亡抑制基因Survivin的异常表达与卵巢癌细胞凋亡抑制及不良预后密切有关。

Abstract

Objective: To investigate clinical significance of survivin expression

cellular apoptosis in ovarian cancer.Method: The apoptosis in sit ovarian cancer were identified by the terminal deoxynucleotidy transfer mediated dUTP-biotin nick end labeling(TUNEL) and survivin expression was detected by immunohistologic staining in 50 cases of ovarian cancer.Result: Survivin was expressed in 36 of 50 ovarian cancer(72%).The correlation was found between survivin expression

cellular apoptosis.The 5 year survival rate in the group of survivin-negative cases was significant higher than in the group of survivin-positive cases(P<0.05).In Cox regression analysis

survivin expression and cellular apoptosis index(AI) were indpendent risk factors for prognosis.Conclusion: Survivin

a inhibitor gene of apoptosis

expression abnormal correlated with apoptosis inhibition

poor prognosis in ovarian cancer.

关键词

卵巢癌Survivin细胞凋亡

Keywords

ovarian cancerSurvivinapoptosis

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