Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits

LUO Cong; et al

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Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits

更新时间：2024-01-17

- Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits
- Journal of Chongqing Medical University Issue 3, Pages: 380-383(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院骨科
  2. 重庆医科大学药理学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2006，
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[1]罗聪,安洪,刘传康,欧云生,杨正钦.复方烫疡油对兔耳瘢痕形成的影响[J].重庆医科大学学报,2006(03):380-383+458.

LUO Cong, et al. Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits. [J]. Journal of Chongqing Medical University (3):380-383(2006)
[1]罗聪,安洪,刘传康,欧云生,杨正钦.复方烫疡油对兔耳瘢痕形成的影响[J].重庆医科大学学报,2006(03):380-383+458. DOI：

LUO Cong, et al. Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits. [J]. Journal of Chongqing Medical University (3):380-383(2006) DOI：

摘要

目的:观察复方烫疡油（FTY）对兔耳腹侧瘢痕形成的影响

探索其作用机制

为临床应用提供依据。方法:用18只新西兰大白兔耳部腹侧制作创伤模型

于每侧兔耳腹侧作四个创面

每个创面1.2cm×1.0cm切除全层皮肤。获144个创面。将兔随机分为两组（A、B组）。A组全部右耳用FTY治疗;全部左耳用复方烫疡油赋形剂（灭菌的芝麻油）治疗;B组全部右耳用磺胺嘧啶银霜治疗;全部左耳用生理盐水治疗。于创伤后30

90天分别取创面组织作组织学观察

并用免疫组织化学法检测Ⅰ、Ⅲ型胶原、转化生长因子-β1（TGF-β1）;TUNEL法定量检测组织细胞的凋亡指数。结果:FTY组创面愈合时间较其它组提前约1.5天。创面增殖块中组织中I、III胶原比值、TGF-β1、细胞核增殖抗原（PCNA）表达较其它组低

凋亡指数FTY组明显高于其它组。结论:复方烫疡油不仅能促进创面愈合

而且能减少创面瘢痕形成。

Abstract

Objective: To investigate the effects of Fu Fang Tang Yang You(复方烫疡油) on the formation of proliferation scars at the ventral side of the ear of rabbits and to explore its possible mechanism.Methods: 144 wounds at the ventral side of the ears of 18 New Zealand white rabbits were created

The area of each wound was 1.2cm×1.0cm.The wounded rabbits were randomly divided into two groups(groups A and B).All the wounds on the right ears of the rabbits in group A were treated with FTY;and the wounds on the left with vegetable oil.All the wounds on the right ears of group B were treated with Sulfadiazine silver cream;and the wounds on the left with normal saline.Tissues from the wounds were examined respectively.30d

60d

90d after injury.Each sample was immunohistochemically stained and examined TGF-β1

type of collagenⅠ?Ⅲ and proliferating cell nuclear antigen(PCNA) monoclonal antibody were examined.The apoptosis index was calculated with TUNEL technique.Results: In FTY group

the time of wound healing was reduced by about 1.5 days;The expression of TGF-β1?PCNA in the tissues of the wounds was lower than that of the control group.Meanwhile

the apoptotic index of fibroblasts was obviously higher than that of the control group.Conclusion: FTY can promote wound healing with less scar formation.

关键词

大黄素创伤瘢痕愈合

Keywords

emodinWoundscarHealing

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