Determination of triptolide in the sustained-release capsule ofTripterygium Wilfordii Hook.f.with HPLC

YU Lurong; et al

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Determination of triptolide in the sustained-release capsule ofTripterygium Wilfordii Hook.f.with HPLC

更新时间：2024-01-17

- Determination of triptolide in the sustained-release capsule ofTripterygium Wilfordii Hook.f.with HPLC
- Journal of Chongqing Medical University Issue 1, Pages: 117-118(2006)
- 作者机构：
  
  1. 重庆医科大学药学系
  2. 重庆医科大学药学系,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R286
- Published：2006，
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[1]喻录容,刘新,明逊,刘碧林.HPLC法测定雷公藤缓释胶囊中雷公藤内酯醇的含量[J].重庆医科大学学报,2006(01):117-118+133.

YU Lurong, et al. Determination of triptolide in the sustained-release capsule ofTripterygium Wilfordii Hook.f.with HPLC. [J]. Journal of Chongqing Medical University (1):117-118(2006)
[1]喻录容,刘新,明逊,刘碧林.HPLC法测定雷公藤缓释胶囊中雷公藤内酯醇的含量[J].重庆医科大学学报,2006(01):117-118+133. DOI：

YU Lurong, et al. Determination of triptolide in the sustained-release capsule ofTripterygium Wilfordii Hook.f.with HPLC. [J]. Journal of Chongqing Medical University (1):117-118(2006) DOI：

摘要

目的:研究雷公藤缓释胶囊的含量测定方法。方法:采用高效液相色谱法

用雷公藤内酯醇为对照品

以乙腈-水（V乙腈:V水=40:60）为流动相

流速1.0m L/m in

色谱柱为C18柱

检测波长为220nm。结果:雷公藤内酯醇在0.047～0.350μg/m l范围内线性关系良好（r=0.9995）

平均回收率为99.88%（RSD=0.58%

n=5）。结论:该方法灵敏度高

准确

重现性好

可作为雷公藤内酯醇的含量测定方法。

Abstract

Objective: To establish a method for content determination of triptolide in the sustained-release capsule of Tripterygium Wilfordii by high performance liquid chromatography.Methods: High performance liquid chromatography was performed on C18 column.The chromatographic conditions were as follows: Acetonitrile-water(40:60) as mobile phase;flow rate being 1.0 ml/min and the detecting wavelength at 220nm.Results:Triptolide had good linear relation within the range from 0.047 to 0.350μg/ml(r=0.9995).The average recovery was 99.88%(RSD=0.58%

n=5).Conclusion: This method is convenient

accurate

reproducible

which can be used for content determinaton of triptolide.

关键词

雷公藤缓释胶囊雷公藤内酯醇含量测定

Keywords

Tripterygium WilfodiiSustained-release capsuleTriptolidecontent determination

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