Clinical study on effect of oxiracetam on mild and moderate brain injury.

XIE Yanfeng; et al

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Clinical study on effect of oxiracetam on mild and moderate brain injury.

更新时间：2024-01-17

- Clinical study on effect of oxiracetam on mild and moderate brain injury.
- Journal of Chongqing Medical University Issue 1, Pages: 113-116(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经外科
  2. 重庆医科大学附属第一医院神经外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R651.15
- Published：2006，
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[1]谢延风,张涛,孙晓川,但炜,唐文渊.奥拉西坦治疗轻中型脑伤的临床研究[J].重庆医科大学学报,2006(01):113-116.

XIE Yanfeng, et al. Clinical study on effect of oxiracetam on mild and moderate brain injury.. [J]. Journal of Chongqing Medical University (1):113-116(2006)
[1]谢延风,张涛,孙晓川,但炜,唐文渊.奥拉西坦治疗轻中型脑伤的临床研究[J].重庆医科大学学报,2006(01):113-116. DOI：

XIE Yanfeng, et al. Clinical study on effect of oxiracetam on mild and moderate brain injury.. [J]. Journal of Chongqing Medical University (1):113-116(2006) DOI：

摘要

目的:通过神经电生理监测来评价益智药奥拉西坦治疗轻中型脑伤的疗效。方法:采用随机双盲对照试验

对照药物为吡拉西坦。将连续收治的48例轻中型脑伤患者随机分入奥拉西坦组和吡拉西坦组

每组24例。分别于用药前、用药21天后进行定量脑电图和P300数据采样。统计分析各组用药前后定量脑电图和P300的差异;比较两种药物对定量脑电图和P300的影响。结果:两组患者用药后的定量脑电图和P300均有明显改善（P<0.05）;奥拉西坦对脑电图和P300的影响较吡拉西坦更大（P<0.05）。结论:奥拉西坦对轻中型脑伤患者脑功能的改善有明显促进作用

且功效较吡拉西坦更强。

Abstract

Objective: To assess the effects of nootropics oxiracetam on mild and moderate brain injure by neuroelectriphisilogy test.Methods: A study of randomised double-blind contrast test was performed with piracetam as contrast medicine.48 consecutive patients with either mild or moderate brain injury were randomly assigned to either oxiracetam group or piracetam group with 24 cases in each group.The recordings of qEEG and P300 were obtained before administration of the agents and 21 days after the treatment.The differences in qEEG and P300 before and after medication were analyzed statistically and effects of the two medicines on qEEG and P300 were compared.Results: The significant improvement in qEEG and P300 was found in both groups after treatment(P<0.05).The effect of oxiracetam on qEEG and P300 was more significant than that of paracetam(P<0.05).Conclusion: Oxiracetam can distinctly improve the brain function of the mild and moderate brain injure

and have better efficacy than piracetam.

关键词

奥拉西坦定量脑电图p300脑外伤

Keywords

OxiracetamqEEGp300Brain injury

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