Expression of VEGF-C in human breast cancer and its implication

GAO Yanchun; et al

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Expression of VEGF-C in human breast cancer and its implication

更新时间：2024-01-17

- Expression of VEGF-C in human breast cancer and its implication
- Journal of Chongqing Medical University Issue 6, Pages: 848-850(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院普外科
  2. 重庆医科大学附属第一医院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2006，
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[1]高砚春,吴诚义.VEGF-C在人乳腺癌中的表达及意义[J].重庆医科大学学报,2006(06):848-850+867.

GAO Yanchun, et al. Expression of VEGF-C in human breast cancer and its implication. [J]. Journal of Chongqing Medical University (6):848-850(2006)
[1]高砚春,吴诚义.VEGF-C在人乳腺癌中的表达及意义[J].重庆医科大学学报,2006(06):848-850+867. DOI：

GAO Yanchun, et al. Expression of VEGF-C in human breast cancer and its implication. [J]. Journal of Chongqing Medical University (6):848-850(2006) DOI：

摘要

目的:探讨血管内皮生长因子-C（VEGF-C）在人乳腺癌组织中的表达及其临床意义。方法:采用免疫组化方法（SP法）检测乳腺纤维腺瘤12例;乳腺囊性增生35例（其中I级增生7例

Ⅱ级增生16例

Ⅲ级增生12例）;乳腺癌45例中VEGF-C的表达情况。结果:VEGF-C在乳腺纤维腺瘤中无表达

在乳腺囊性增生中的表达率为20.0%（7/35）

其中I级为0

Ⅱ级12.5%（2/16）

Ⅲ级41.7%（5/12）。在乳腺癌中的表达率为71.1%（32/45）

与乳腺增生比较差异显著（P<0.05）。VEGF-C在Ⅲ+Ⅳ期乳腺癌中的表达率明显高于I+Ⅱ期乳腺癌

其相应淋巴结的转移率也愈高（P<0.05）

但与患者年龄、肿瘤大小、雌激素、孕激素受体状况等无明显相关性。结论:VEGF-C在乳腺癌发生恶变的过程中起着重要作用

其高表达预示患者易于发生淋巴结转移。

Abstract

Objective:To investigate the relationship between the expression of vascular endothelial growth factor-C(VEGF-C) proteins and biological behavior of breast cancer.Methods:Immunohistochemical staining was used to detect the expression of VEGF-C proteins in 12 cases of mammary fibroma

35 cases of mammary cystic hyperplasia

45 cases of breast cancer.Results:VEGF-C protein was absent in mammary fibroma

the expression rate of VEGF-C protein in mammary cystic hyperplasia was 20.0%(7/35)

The expression rate of VEGF-C in breast cancer was 71.1%(32/45)

and it was significantly different compared with mammary cystic hyperplasia(P<0.05).The expression of VEGF-C in Ⅲ and Ⅳ phase of breast cancer were significantly higher than that in Ⅰand Ⅱ phase

so was the axillary lymph node metastasis rate(P<0.05).However

it was not correlated with the age of patient

tumor size

the expression of ER and PR.Conclusions:VEGF-C may take part in occurrence and progression of breast cancer.Over-expression of VEGF-C is related to high possibility of lymphatic metastasis.

关键词

乳腺肿瘤VEGF-C淋巴转移

Keywords

Breast cancerVEGF-CLymphatic metastasis

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