Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models

XIONG Yin; et al

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Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models

更新时间：2024-01-17

- Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models
- Journal of Chongqing Medical University Issue 6, Pages: 845-847(2006)
- 作者机构：
  
  1. 重庆医科大学药学院药理教研室
  2. 重庆医科大学药学院药理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2006，
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[1]熊缨,余华荣,杨菊,周岐新.外源性给予喹啉酸对急性和亚急性炎症动物模型的作用[J].重庆医科大学学报,2006(06):845-847.

XIONG Yin, et al. Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models. [J]. Journal of Chongqing Medical University (6):845-847(2006)
[1]熊缨,余华荣,杨菊,周岐新.外源性给予喹啉酸对急性和亚急性炎症动物模型的作用[J].重庆医科大学学报,2006(06):845-847. DOI：

XIONG Yin, et al. Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models. [J]. Journal of Chongqing Medical University (6):845-847(2006) DOI：

摘要

目的:考察喹啉酸对小鼠急性和亚急性炎症的影响。方法:选取昆明种小鼠或者Wistar大鼠

分别进行喹啉酸对二甲苯耳壳肿胀小鼠模型、羧甲基纤维素（CMC）囊法大鼠模型、醋酸-伊文思兰腹腔毛细血管通透性模型、大鼠棉球肉芽肿模型的影响

以及对小鼠碳粒廓清法模型的影响。结果:喹啉酸对二甲苯所致小鼠耳壳肿胀、CMC所致大鼠背囊内白细胞聚集和醋酸所致小鼠腹腔毛细血管通透性增加以及大鼠棉球肉芽肿的增生有明显的抑制作用

对小鼠碳粒廓清法测得的巨噬细胞吞噬功能亦有抑制作用。结论:喹啉酸对急性和亚急性炎症具有较好的抗炎作用和一定的免疫抑制作用。

Abstract

Objective: To investigate the anti-inflammatory effects of quinolinic acid.Methods: Kunming mouse or Wistar rat was selected to proceed experiments.Influences of quinolinic acid on tumidness caused by dimethylbenzene in mouse’s ear

on wandering of rat WBC caused by CMC injection

on increasement of mouse capillary vessel permeability caused by acetic acid

on granuloma in rat’s armpit caused by tampon and phagocytosis of mouse were investigated

respectively.Results: Obvious suppression of all the inflammatory models was observed.Conclusion:Exogenous quinolinic acid is endowed with quite evident anti-inflammatory effects on either acute or subacute animal models with somewhat immunological inhibition.

关键词

喹啉酸炎症

Keywords

Quinolinic acidinflammation

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