A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.

YUAN Zhe; et al

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A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.

更新时间：2024-01-17

- A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.
- Journal of Chongqing Medical University Issue 4, Pages: 542-546(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院感染科重庆市传染病寄生虫病学重点实验室
  2. 海南省人民医院
  3. 海南医学院附属医院
  4. 海南省海口市人民医院
  5. 海南省农垦总局医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R691.3
- Published：2006，
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[1]袁喆,贾杰,钟良宝,刘振湘,陈文.多西环素与阿奇霉素随机双盲对照治疗泌尿系统感染[J].重庆医科大学学报,2006(04):542-546.

YUAN Zhe, et al. A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.. [J]. Journal of Chongqing Medical University (4):542-546(2006)
[1]袁喆,贾杰,钟良宝,刘振湘,陈文.多西环素与阿奇霉素随机双盲对照治疗泌尿系统感染[J].重庆医科大学学报,2006(04):542-546. DOI：

YUAN Zhe, et al. A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.. [J]. Journal of Chongqing Medical University (4):542-546(2006) DOI：

摘要

目的:评价国产盐酸多西环素注射液治疗泌尿系统感染的有效性和安全性。方法:采用多中心随机对照双盲试验。试验药盐酸多西环素注射液静脉滴注

每次200mg

每日1次

疗程5～12天。对照药阿奇霉素每次500mg

每日1次

静脉滴注

疗程5～12天。结果:试验组与对照组可进行安全性评价者分别有63

60例;可进行疗效评价者分别有62

60例。试验组痊愈率90.32%、临床有效率100%、细菌清除率92.5%、对支原体的清除率为94.1%;对照组分别为73.33%

95%

88.9%

76.7%

两组比较

痊愈率差异有统计学意义（P<0.05）。多西环素对革兰阳性菌体外抗菌活性优于其他几种抗生素。对革兰阴性菌的抗菌活性与其他几种抗生素相近或略优。不良事件的发生率分别为7.9%和6.7%

2组比较差异无统计学意义（P>0.05）。结论:国产多西环素抗菌谱广、抗菌活性强

是一个高效、安全的抗菌药物

治疗敏感菌及支原体引起的泌尿系统感染疗效确切

安全性好。

Abstract

Objective: To evaluate the safety and efficacy of domestic intravenous doxycycline in the treatment of urinary tract infections.Methods:A multicenter

double-blind

randomized controlled clinical trial of intravenous doxycycline and azithromycin on patients with urinary tract infections were conducted.The dosage of doxycycline was 0.2g

once daily

for 5~12d and that of azithromycin was 0.5g

once daily

for 5~12d.Both drugs were given intravenously.Results: In this trial

62 patients were enrolled in doxycycline group

and 60 were enrolled in azithromycin group.The overall efficacy rates and cure rate in trial and control group were 100%

90.32% and 73.33%

95% respectively.There was statistical significant difference in the cure rates between the two groups.The bacterial clearance rates in two groups were 92.5% and 88.9% respectively.The adverse drug reaction rates were7.9% and6.7% respectively.There were no statistical significant differences in the above results between the two groups.The activity of doxycycline against gram-positive organisms was generally higher than that of the other 5 antibacterial agents.Antibacterial activity of doxycycline against gram-negtive bacterium was similar to or stronger than the other antibacterial agents.Conclusion: The results suggest that domestic doxycycline injection with powerful antibacterial activity and wide spectrum is highly effective in treating urinary tract infections.

关键词

多西环素阿奇霉素泌尿系统感染随机对照试验双盲法多中心研究

Keywords

DoxycyclineAzithromycinUrinary tract infectionsRandomized controlledDouble-blind testMulti-center clinical research

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