Investigation of verapamil reverse the drug resistance of KBV200 cell line

CHEN Hongyan; et al

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Investigation of verapamil reverse the drug resistance of KBV200 cell line

更新时间：2024-01-17

- Investigation of verapamil reverse the drug resistance of KBV200 cell line
- Journal of Chongqing Medical University Issue 4, Pages: 537-541(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院耳鼻咽喉科
  2. 重庆医科大学基础医学院
  3. 重庆医科大学附属儿童医院耳鼻喉科
  4. 汕头大学医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.65
- Published：2006，
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[1]陈鸿雁,王驰,舒艳,陈燕,吕彩凤,张潜英,沈娜,余晓燕,叶玲,蒋纪恺.维拉帕米对喉癌细胞株耐药逆转作用研究[J].重庆医科大学学报,2006(04):537-541+581.

CHEN Hongyan, et al. Investigation of verapamil reverse the drug resistance of KBV200 cell line. [J]. Journal of Chongqing Medical University (4):537-541(2006)
[1]陈鸿雁,王驰,舒艳,陈燕,吕彩凤,张潜英,沈娜,余晓燕,叶玲,蒋纪恺.维拉帕米对喉癌细胞株耐药逆转作用研究[J].重庆医科大学学报,2006(04):537-541+581. DOI：

CHEN Hongyan, et al. Investigation of verapamil reverse the drug resistance of KBV200 cell line. [J]. Journal of Chongqing Medical University (4):537-541(2006) DOI：

摘要

目的:（1）研究喉癌多药耐药细胞株的耐药谱

为实现临床化学治疗个体化提供实验依据。（2）研究维拉帕米对喉癌细胞株耐药逆转浓度及耐药逆转谱。方法:以喉癌KBV200耐药细胞株为研究对象:（1）采用MTT法检测临床常用8种抗肿瘤药物对该细胞株的增殖抑制作用。（2）采用MTT法检测维拉帕米对喉癌细胞株耐药逆转作用。结果:（1）长春新碱、阿霉素、平阳霉素、环磷酰胺、阿糖胞苷对KBV200耐药细胞株的抑制作用差

三尖杉酯、5-Fu及顺铂对KBV200耐药细胞株的抑制作用好。（2）维拉帕米（12.5μg/ml）能逆转长春新碱、阿霉素、平阳霉素、环磷酰胺对KBV200耐药细胞株的耐药作用。结论:（1）KBV200耐药细胞株对长春新碱、阿霉素、平阳霉素、环磷酰胺、阿糖胞苷5种药物有不同程度耐药。（2）维拉帕米（12.5μg/ml）对KBV200耐药细胞株的耐药逆转谱是长春新碱、阿霉素、平阳霉素、环磷酰胺。

Abstract

Objective: To make a study of KBV200 cell line on its multidrug resistance and provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of 8 common chemotherapetic agents on KBV200 cell line.Result:Vincristine、Adriamycin、Bleomycin、Cyclophosphamide and Arabinosyl Cytosine have poorer inhibition than Harrihgtonine、Cicplatin and 5-Fu on KBV200 cell line.Conclusion:KBV200 cell line is multidrug resistance to Vincristine、Adriamycin、Bleomycin、Cyclophosphamide and Arabinosyl Cytosine.

关键词

抗肿瘤药KBV200细胞株MTT维拉帕米

Keywords

Chemotherapetic agentsKBV200 cell lineMTTVerapamil

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LU Li

CHEN Hongyan

叶玲

张潜英

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吕彩凤

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Department of Otolaryngology,the First Affilated Hospital,Chongqing Medical University

Department of Otolaryngology,the First Affiliate Hospital,Chongqing Medical University

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