Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice

QIU Hongmei; et al

您当前的位置：

首页 >

文章列表页 >

Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice

更新时间：2024-01-17

- Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice
- Journal of Chongqing Medical University Issue 4, Pages: 547-551(2006)
- 作者机构：
  
  1. 重庆医科大学重庆市生物化学与分子药理学重点实验室
  2. 重庆医科大学重庆市生物化学与分子药理学重点实验室,重庆,400016
  3. 教授,重庆,400016
  4. 博士生导师
- 作者简介：
- 基金信息：
- DOI：
  CLC： R114
- Published：2006，
扫描看全文
[1]邱红梅,何百成,周歧新.铝过负荷致小鼠神经退行性变与氧化应激和抗氧化应激系统关系的研究[J].重庆医科大学学报,2006(04):547-551.

QIU Hongmei, et al. Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice. [J]. Journal of Chongqing Medical University (4):547-551(2006)
[1]邱红梅,何百成,周歧新.铝过负荷致小鼠神经退行性变与氧化应激和抗氧化应激系统关系的研究[J].重庆医科大学学报,2006(04):547-551. DOI：

QIU Hongmei, et al. Study of the relationship between aluminum overload-induced neurodegeneration and systems of oxidative stress and anti-oxidative stress in mice. [J]. Journal of Chongqing Medical University (4):547-551(2006) DOI：

摘要

目的:研究铝过负荷致小鼠神经元退行性变与脑内氧化应激系统和抗氧化应激系统之间的关系。方法:采用氯化铝溶液（相当于400 mg/kg Al3+）灌胃小鼠

每天1次

1周6天

连续3月

建立铝过负荷所致小鼠神经元退行性变模型。以被动回避性学习记忆能力和空间识别能力的改变、大脑皮层和海马总SOD、SOD2活性和MDA含量变化、以及海马病理学改变为观察指标。结果:铝过负荷能明显导致小鼠进行性被动回避性学习记忆和空间识别能力障碍;出现海马神经元核固缩和神经元丢失;脑组织总SOD和SOD2活性及MDA含量呈平行变化

出现先升高后降低趋势

但各时点SOD和SOD2活性及MDA含量均明显高于对照组。结论:铝过负荷明显致小鼠神经元退行性变

学习记忆能力下降。其机制可能与铝负荷引起脑内氧化应激反应和抗氧化应激系统动员失恒有关。

Abstract

Objective: To study the roles of the oxidative stress system and the anti-oxidative stress system in neurodegenerative processes induced by aluminum overload in mice.Methods: The neurodegenerative model of mice was established via intragastric administration of AlCl3 solution(element aluminum 400 mg/kg)once a day

with 6 days of week for 3 months.The light-dark test and morris-water-maze were used to evaluate the learning and memory functions.The activities of SOD and SOD2 as well as the contents of MDA in both cortices and hippocampi were measured.Pathomorphological changes of hippocampi were observed.Results: Aluminum overload significantly decreased capacity of passive avoidance learning and memory and spatial recognition

caused the pyknosis and neuron loss of hippocampi

and parallelly increased SOD and SOD2 activities as well as MDA content in cortex and hippocampi

with a tendency of raising first and then gradually decreasing.Conclusions: Aluminum overload markedly causes neurodegeneration and damages learning and memory function in mice

the mechanism of which may be related to the imbalance between oxidative stress and anti-oxidative stress systems in brain induced by aluminum overload.

关键词

铝过负荷神经系统退行性改变SODSOD2MDA

Keywords

Aluminum overloadNeurodegenerationSODSOD2MDA

references

Views

183

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Biological effect of ultrasound-mediated microbubble destruction on sertoli cells

EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT

Correlation between aluminum overload-induced brain neurodegeneration and monoamine oxidase B in mouse brain

Related Author

ZHANG bo

et al

林艳君

王志刚

傅仲学

韩文妙

WU Ke

et al

Related Institution

Department of Urology,the Second Affiliated Hospital,Chongqing Medical University

重庆医科大学超声影像学研究所

重庆医科大学第一医院普外科

Department of Pharmacology,School of Pharmacy,Chongqing Medical University

重庆医科大学药学院药理教研室

⁰