Functions of vascular endothelial growth factor,estrogen receptor and progesterone receptor in the pathogenesis mechanism of hypomenorrhea

YUAN Rui et al

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Functions of vascular endothelial growth factor,estrogen receptor and progesterone receptor in the pathogenesis mechanism of hypomenorrhea

更新时间：2024-01-17

- Functions of vascular endothelial growth factor,estrogen receptor and progesterone receptor in the pathogenesis mechanism of hypomenorrhea
- Journal of Chongqing Medical University Issue 1, Pages: 48-51(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.5
- Published：2007，
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[1]袁瑞,乐爱文,姚珍薇,耿力.ER、PR、VEGF及其受体在原因不明月经过少发病机制中的作用[J].重庆医科大学学报,2007(01):48-51.

YUAN Rui et al. Functions of vascular endothelial growth factor,estrogen receptor and progesterone receptor in the pathogenesis mechanism of hypomenorrhea. [J]. Journal of Chongqing Medical University (1):48-51(2007)
[1]袁瑞,乐爱文,姚珍薇,耿力.ER、PR、VEGF及其受体在原因不明月经过少发病机制中的作用[J].重庆医科大学学报,2007(01):48-51. DOI：

YUAN Rui et al. Functions of vascular endothelial growth factor,estrogen receptor and progesterone receptor in the pathogenesis mechanism of hypomenorrhea. [J]. Journal of Chongqing Medical University (1):48-51(2007) DOI：

摘要

目的:通过对子宫内膜组织中雌激素受体（ER）、孕激素受体（PR）、血管内皮生长因子(（VEGF）及其受体（KDR）表达的研究

探讨原因不明月经过少的发病机制。方法:2004年9月至2005年12月重庆医科大学附属第一医院以前瞻性方法观察月经过少组（观察组）和正常月经组（对照组）患者各40例

采用酶联免疫测定法

测定两组血清6项性激素

包括卵泡刺激素（FSH）、黄体生成素（LH）、雌激素（E2）、催乳素（PRL）、孕酮（P）及睾酮（T）

通过免疫组化半定量测定两组子宫内膜组织中ER、PR、VEGF、KDR的表达水平。结果:两组血清性激素水平FSH、LH、E2、PRL、P及T差异无显著性意义（P>0.05）;观察组子宫内膜ER、VEGF和KDR的表达明显低于对照组（P值分别为<0.05）;两组子宫内膜腺上皮细胞PR的表达差异无显著性意义（P>0.05）。结论:子宫内膜组织中ER、VEGF和KDR的异常表达可能导致原因不明的月经过少。

Abstract

Objective:To discuss the possible pathogenesis mechanisms of hypomenorrhea by investigating the expression of estrogen receptors(ER)

progesterone receptors(PR)

vascular endothelial growth factor(VEGF)and kinase insert domaincontaining receptor(KDR)in the endometrium.Methods:We designed a prospective study on forty patients with hypomenorrhea as study group

and forty women with normal menorrea as control

all of them being treated in The First Affiliated Hospital Of Chongqing Medical University between September

2004 and December

2005.Follicle stimulatinghormone(FSH)

luteinizinghormone(LH)

estradiol(E2)

prolactin(PRL)

progesterone(P)and testosterone(T)were examined by ELISA.And the expression of ER、PR、VEGF and KDR were examined by immunohistochemical semiquantitative nalysis.Results:There was no significant difference in FSH

PRL

P and T between the two groups(P>0.05).The expressions were remarkably of endometrial ER、VEGF and KDR in the study group as extremely lower than those in the control group

and the statistical difference between the two groups were all significant(P<0.05).And there was no significant difference in the expression of PR between the two groups(P>0.05).Conclusion:ER、VEGF and KDR may be relevant to the occurrence of hypomenorrhea.

关键词

月经过少血管内皮生长因子雌激素受体孕激素受体

Keywords

HypomenorrheaVascular endothelial growth factor (VEGF)Estrogen receptors(ER)Progesterone receptors(PR)

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