Prediction of chemosensitivity to combination neoadjuvant chemotherapy with carboplatin and 5-Fu for the patients with oral squamous cell carcinoma

YANG Kai; et al

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Prediction of chemosensitivity to combination neoadjuvant chemotherapy with carboplatin and 5-Fu for the patients with oral squamous cell carcinoma

更新时间：2024-01-17

- Prediction of chemosensitivity to combination neoadjuvant chemotherapy with carboplatin and 5-Fu for the patients with oral squamous cell carcinoma
- Journal of Chongqing Medical University Issue 6, Pages: 798-800(2006)
- 作者机构：
  
  1. 重庆医科大学附属第一医院口腔颌面外科
  2. 重庆医科大学基础医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.8
- Published：2006，
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[1]杨凯,吴明军,孙德平,陈睿.口腔鳞癌对卡铂联合5-Fu新辅助化疗方案敏感性的预测研究[J].重庆医科大学学报,2006(06):798-800.

YANG Kai, et al. Prediction of chemosensitivity to combination neoadjuvant chemotherapy with carboplatin and 5-Fu for the patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University (6):798-800(2006)
[1]杨凯,吴明军,孙德平,陈睿.口腔鳞癌对卡铂联合5-Fu新辅助化疗方案敏感性的预测研究[J].重庆医科大学学报,2006(06):798-800. DOI：

YANG Kai, et al. Prediction of chemosensitivity to combination neoadjuvant chemotherapy with carboplatin and 5-Fu for the patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University (6):798-800(2006) DOI：

摘要

目的:探讨新辅助化疗前增殖细胞核抗原（PCNA）和P53在口腔鳞癌组织中的表达水平及其对卡铂联合5-氟脲嘧啶化疗方案（CF方案）敏感性预测的价值。方法:采用SP免疫组化法

对50例T2～T4口腔鳞癌患者用CF方案行2疗程新辅助化疗前后PCNA和P53的表达水平进行检测

分析其表达水平与化疗疗效的关系。结果:①化疗前口腔鳞癌中PCNA和P53的表达水平与化疗疗效显著相关（P<0.05）;②化疗前PCNA高表达同时P53表达阴性患者行CF方案化疗有效率为90.00%

显著高于其它表达类型（P<0.05）

PCNA低表达同时P53表达阳性的患者

CF方案化疗的有效率为14.29%

显著低于其它表达类型（P<0.05）。结论:化疗前PCNA和P53的表达水平均可作为预测口腔鳞癌对CF化疗方案敏感性的分子标记物

但用PCNA和P53两项指标的表达水平来联合预测显著高于单项指标预测。

Abstract

Objective:To investigate the expression of P53and proliferating cell nuclear antigen(PCNA)in oral squamous cell carcinoma(OSCC)and its chemosensitive predictive value to neoadjuvant chemotherapy(NACT) with Carboplatin and 5-Fu for the patients with OSCC.Methods:50 patients with T2～T4 OSCC were examined by using SP immunohistochemistry before and after two NACT courses.the correlation between expression level of PCNA and P53 and therapeutic effect was analyzed.Results:①Expression level of PCNA and P53 was significantly associated with response to chemotherapy(P <0.05);② The effective rates of PCNA high expression and P53 negative expression in OSCC before NACT was 90.00%

it was significantly higher than that of other expression types(P <0.05)

and the effective rates of PCNA low expression and P53 positive expression was 14.29%

it was significantly lower than that of other expression types(P <0.05).Conclusion:Expression level of both PCNA and P53 can be used as a chemosensitive predictive marker to neoadjuvant chemotherapy with Carboplatin and 5-Fu for the patients with OSCC

and combined analysis of PCNA and P53 expression has higher predictive value than that of either PCNA or P53.

关键词

新辅助化疗化学治疗增殖细胞核抗原p53口腔鳞癌敏感性疗效

Keywords

neoadjuvant chemotherapychemotherapyPCNAp53oral squamous cell carcinomaChemosensitivityChemotherapy efficiency

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