Objective:To explore the effects of peroxisome proliferator-actived receptors-γ(PPAR-γ)agonists rosiglitazone and non-steroidal anti-inflammatory drugs(NSAIDs) ibuprofen on tumor necrosis factor-α(TNF-α)mRNA expression in the brain of rats with acute experimental autoimmune encephalomyelitis(EAE).Methods:EAE models on rat were established by inoculating the homogenate containing spinal cord of guinea pig and complete Freund’s adjuvant

and then treated by rosiglitazone and ibuprofen respectively.The improvement of clinical manifestations was assessed to determine the curative effect of the two medicines and TNF-α mRNA expression level was detected by RT-PCR.Results:Compared with EAE group

the groups with rosiglitazone and ibuprofen showed improvement in clinical manifestations

and the expression of TNF-α mRNA reduced markedly(P<0.01).Other index of the treated groups were no significantly different(P>0.05).Conclusions:PPAR-γ agonists rosiglitazone and NSAIDs ibuprofen could obviusely improve the clinical manifestations of EAE rats

and decrease the level of the expression of TNF-α mRNA

which suggested PPAR-γ agonists may have the anti-inflammation neural protective function on EAE or multiple sclerosis(MS)

and the anti-inflammation of ibuprofen may be related to the activation of PPAR-γ.