Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance

WU Jingxian; et al

您当前的位置：

首页 >

文章列表页 >

Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance

更新时间：2024-01-17

- Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance
- Journal of Chongqing Medical University Issue 11, Pages: 1165-1168(2007)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理学教研室
  2. 重庆医科大学基础医学院病理学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.31
- Published：2007，
扫描看全文
[1]巫静娴,赵涌,贾世军,李圆圆.CD147与基质金属蛋白酶-2,3,9在卵巢癌中的表达及临床病理意义[J].重庆医科大学学报,2007(11):1165-1168+1184.

WU Jingxian, et al. Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance. [J]. Journal of Chongqing Medical University (11):1165-1168(2007)
[1]巫静娴,赵涌,贾世军,李圆圆.CD147与基质金属蛋白酶-2,3,9在卵巢癌中的表达及临床病理意义[J].重庆医科大学学报,2007(11):1165-1168+1184. DOI：

WU Jingxian, et al. Expressions of MMP-2,MMP-3,MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance. [J]. Journal of Chongqing Medical University (11):1165-1168(2007) DOI：

摘要

目的:检测CD147和基质金属蛋白酶（MMP）-2

9在卵巢癌中的表达

了解其与卵巢癌临床病理特征之间的关系

探讨卵巢癌中CD147与MMP-2、MMP-3和MMP-9表达的相关性。方法:用免疫组化SP法对40例卵巢癌组织

9例良性卵巢上皮性肿瘤组织中CD147和MMP-2、MMP-3、MMP-9的表达情况进行检测。结果:CD147和MMP-2、MMP-3及MMP-9在卵巢癌中的阳性表达率分别为92.5%

100%

100%和95%

阳性表达与病理分级和临床分期有关（P<0.05）

与组织学类型无关

与临床预后无显著相关（P>0.05）。在卵巢癌中

CD147与MMP-2、MMP-3和MMP-9多同时表达

呈现出显著正相关

Abstract

Objective:To investigate the expressions of MMP-2

MMP-3

MMP-9 and CD147 in human ovarian cancer and their clinicopathological significance.Methods:Immunohisto chemical S-P method was performed to detect the expressions of MMP-2

MMP-3

MMP-9

CD147 in 40 malignant and 9 benign ovarian tumors.Result:The expression rates of MMP-2

MMP-3

MMP-9 and CD147 in ovarian cancer were 92.5%

100%

100% and 95%

respectively.The expressions of MMP-2

MMP-3

MMP-9 and CD147 in ovarian cancer were related with clinical stage and pathological garade(P<0.05)but not with the histological type and clinical prognosis(P>0.05).There were positive correlations between the expressions of CD147 and MMP-2

MMP-3

MMP-9(r=0.802

0.786

0.914)in ovarian cancer.Conclusion:Expressions of CD147

MMP-2

MMP-3 and MMP-9 have relevance to clinical stages and pathological grades in ovarian cancer

and overexpression of CD147 may induce the secretion of MMP-2

MMP-3

MMP-9.

关键词

CD147基质金属蛋白酶-2基质金属蛋白酶-3基质金属蛋白酶-9卵巢癌免疫组化

Keywords

CD147Matrix metalloproteinase-9Matrix metalloproteinase-2Matrix metalloproteinase-3ovarian cancerImmuno-histochemistry

references

Views

207

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

SP1 mediates CD147 to influence the angiogenesis of ovarian cancer through HIF-1α/VEGF signaling pathway

RNAi technology applied to the preparation of molecular probes for diagnosis and treatment of ovarian cancer

Effect of silencing mdrl gene by RNA interference with adriamycin on proliferation of SKOV₃/ADM

Related Author

Sun Lisha

Qu Bin

Yang Yongwen

Shan Dongyong

Shen Haoming

Deng Hongyu

Sun Lisha

Wen Ming

Related Institution

Department of Blood Transfusion, Hunan Cancer Hospital

Department of Clinical Laboratory,Hunan Cancer Hospital

Oncology Radiotherapy Center,The Third Xiangya Hospital of Central South University

Department of Clinical Laboratory,The First Xiangya Hospital of Central South University

Department of Radiology,The First Affiliated Hospital of Chongqing Medical University

⁰