Effect of varicocele on expression of HIF-1α and VEGF in germ cells of adolescent rats

LV Tianbing; et al

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Effect of varicocele on expression of HIF-1α and VEGF in germ cells of adolescent rats

更新时间：2024-01-17

- Effect of varicocele on expression of HIF-1α and VEGF in germ cells of adolescent rats
- Journal of Chongqing Medical University Issue 11, Pages: 1169-1171(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 四川省内江市第一人民医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R697.2
- Published：2007，
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[1]吕天兵,苟欣,高斌,余周,吴跃.精索静脉曲张对青春期大鼠睾丸生精细胞HIF-1α和VEGF表达的影响[J].重庆医科大学学报,2007(11):1169-1171.

LV Tianbing, et al. Effect of varicocele on expression of HIF-1α and VEGF in germ cells of adolescent rats. [J]. Journal of Chongqing Medical University (11):1169-1171(2007)
[1]吕天兵,苟欣,高斌,余周,吴跃.精索静脉曲张对青春期大鼠睾丸生精细胞HIF-1α和VEGF表达的影响[J].重庆医科大学学报,2007(11):1169-1171. DOI：

LV Tianbing, et al. Effect of varicocele on expression of HIF-1α and VEGF in germ cells of adolescent rats. [J]. Journal of Chongqing Medical University (11):1169-1171(2007) DOI：

摘要

目的:研究精索静脉曲张（VC）对大鼠睾丸生精细胞低氧诱导因子-1α（Hypoxia-induciblefactor-1α、HIF-1α）和VEGF表达的影响

探索精索静脉曲张引起不育的机理。方法:采用青春期雄性Wistar大鼠复制左侧精索静脉曲张模型

分别于术后30天、60天处死、取左侧睾丸

用免疫组化SP法检测HIF-1α和VEGF的表达。结果:HIF-1α和VEGF在VC组左侧睾丸组织中的表达均明显高于假手术组（SOG）

随着精索静脉时间延长

HIF-1α、VEGF表达降低

但仍高于假手术组。结论:实验性精索静脉曲张可以改变青春期大鼠睾丸组织生精细胞HIF-1α和VEGF的表达。

Abstract

Objective:To study the effect of varicocele(VC)on Expression of hypoxia-inducible factor-1α(HIF-1α)and vascular endothelial growth factor(VEGF)in germ cells of adolescent rats

and investigate the mechanism of the infertility resulting from varicocele.Methods:The varicocele model was created by partial ligation of the left renal vein in adolescent male Wistar rats

a total of 50 rats were randomly divided into four groups

namely varicocele group

sham operation group(SOG)

At 30 days and 60 days were completed

left orchiectomy was performed the expression of HIF-1α and VEGF were detected by immunohistochemical method.Results:The expression of HIF-1α and VEGF in left testes of varicocele group is significantly higher than of sham operation group.With the duration of varicocele mode1

HIF-1α and VEGF expression in experiment group was decreased

but was higher compared with that in control group.Conclusion:Experimental varicocele could change Expression of hypoxia-inducible factor-1α(HIF-1α)and VEGF in germ cells of adolescent rats.

关键词

精索静脉曲张生精细胞HIF-1αVEGF

Keywords

varicoceleGerm cellHypoxia-inducible factor-1αvascular endothelial growth factor

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