The concentration of basal cortisol and its correlation analysis in patients with polycystic ovarian syndrome

CHENG Qingfeng; et al

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The concentration of basal cortisol and its correlation analysis in patients with polycystic ovarian syndrome

更新时间：2024-01-17

- The concentration of basal cortisol and its correlation analysis in patients with polycystic ovarian syndrome
- Journal of Chongqing Medical University Issue 11, Pages: 1162-1164(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.75
- Published：2007，
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[1]程庆丰,李启富,冯静,白晓苏,青华,刘秀容,张素华.多囊卵巢综合征患者空腹皮质醇浓度测定及其相关因素分析[J].重庆医科大学学报,2007(11):1162-1164+1171.

CHENG Qingfeng, et al. The concentration of basal cortisol and its correlation analysis in patients with polycystic ovarian syndrome. [J]. Journal of Chongqing Medical University (11):1162-1164(2007)
[1]程庆丰,李启富,冯静,白晓苏,青华,刘秀容,张素华.多囊卵巢综合征患者空腹皮质醇浓度测定及其相关因素分析[J].重庆医科大学学报,2007(11):1162-1164+1171. DOI：

CHENG Qingfeng, et al. The concentration of basal cortisol and its correlation analysis in patients with polycystic ovarian syndrome. [J]. Journal of Chongqing Medical University (11):1162-1164(2007) DOI：

摘要

目的:测定多囊卵巢综合征（PCOS）患者空腹血浆皮质醇浓度

并分析其相关影响因素。方法:84例PCOS患者分为超重或肥胖组（34例）和正常体重组（50例）

对照组为年龄匹配的健康妇女（20例）。测定空腹皮质醇、葡萄糖、胰岛素水平及胰岛素敏感性（葡萄糖钳夹技术评价）。结果:与正常体重PCOS组和正常对照组相比

超重或肥胖PCOS患者的空腹血浆皮质醇水平下降（P<0.05）。对所有PCOS患者的空腹皮质醇进行多元回归分析提示

PCOS患者空腹皮质醇与体重指数、胰岛素敏感性、空腹胰岛素呈负相关。结论:超重或肥胖PCOS患者空腹皮质醇水平降低。PCOS患者空腹皮质醇水平不仅与体重有关

还与胰岛素敏感性和空腹胰岛素水平有关。

Abstract

Objective:To measure the basal concentration of cortisol and analyze its associations with correlative factors in patients with Polycystic Ovarian Syndrome(PCOS).Methods:34 obese(or overweight)and 50 normally-weighed women with PCOS and 21 age-matched healthy women were recruited.Fasting plasma cortisol

insulin

glucose and insulin sensitivity(with euglycemic clamp technique)were measured.Results:Basal cortisol level in the obese or overweight patients with PCOS was lower than in normal weight PCOS and control groups(P<0.05).In the patients with PCOS

multiple linear regression analysis showed that basal cortisol correlated negatively with body mass index

insulin sensitivity and fasting insulin level.Conclusion:The obese or overweight patients with PCOS have significantly decreased basal cortisol level.Basal level of cortisol correlates not only with body weight

but also with insulin sensitivity and fasting insulin level in patients with PCOS.

关键词

多囊卵巢综合征皮质醇胰岛素抵抗

Keywords

polycystic ovary syndromeCortisolinsulin resistance

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