Clinical efficacy and safety of lornoxicam used in patient-controlled analgesia for renal transplatation

GAO Jin; et al

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Clinical efficacy and safety of lornoxicam used in patient-controlled analgesia for renal transplatation

更新时间：2024-01-17

- Clinical efficacy and safety of lornoxicam used in patient-controlled analgesia for renal transplatation
- Journal of Chongqing Medical University Issue 10, Pages: 1074-1077(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院麻醉科
  2. 重庆医科大学附属第一医院麻醉科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R614
- Published：2007，
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[1]高进,陈萍.氯诺昔康用于肾移植患者术后镇痛的疗效和安全性的临床观察[J].重庆医科大学学报,2007(10):1074-1077.

GAO Jin, et al. Clinical efficacy and safety of lornoxicam used in patient-controlled analgesia for renal transplatation. [J]. Journal of Chongqing Medical University (10):1074-1077(2007)
[1]高进,陈萍.氯诺昔康用于肾移植患者术后镇痛的疗效和安全性的临床观察[J].重庆医科大学学报,2007(10):1074-1077. DOI：

GAO Jin, et al. Clinical efficacy and safety of lornoxicam used in patient-controlled analgesia for renal transplatation. [J]. Journal of Chongqing Medical University (10):1074-1077(2007) DOI：

摘要

目的:评价氯诺昔康复合曲马多用于肾移植患者术后静脉自控性镇痛（Patient-controlled analgesia

PCA）的疗效和安全性

为临床提供参考。方法:60例全身麻醉下行肾移植术后出现疼痛的患者随机分为沙菲复合曲马多组（I组）和氯诺昔康复合曲马多组（Ⅱ组）。患者根据需要启动PCA泵。由疼痛VAS评分和患者24h镇痛总体效果来评价镇痛效果

同时监测凝血功能、移植肾存活情况

并观察呼吸、镇静、胃肠道反应等。结果:术毕1h内

氯诺昔康复合曲马多组VAS评分和按压次数多于沙菲复合曲马多组

差异有显著性

沙菲复合曲马多组起效早于氯诺昔康复合曲马多组。1h后两组VAS评分、按压次数、镇痛总体印象评分、对呼吸影响差异无显著性。氯诺昔康复合曲马多组的恶心呕吐与镇静评分明显低于沙菲复合曲马多组

排气时间也短于沙菲复合曲马多组。氯诺昔康复合曲马多组术后1天凝血功能指标PT、APTT较沙菲复合曲马多组有所延长

但几乎在临床范围内

无临床价值。两组患者移植肾均存活。结论:氯诺昔康复合曲马多可以安全的用于肾移植患者的术后镇痛

其镇痛效应与沙菲复合曲马多相近

但不良反应较少

尤其是胃肠道反应明显轻于沙菲复合曲马多组

但对术前凝血功能明显障碍的患者

应慎用或不用。

Abstract

0bjective:To compared the efficacy and safety of lornoxicam combined with tramadol used in patient-controlled analgesia (PCA) in patients undergoing renal transplatation. Methods:60 patients renal transplatation were randomly divided into Buprenorphine combined with tramadol group(I group) and lornoxicam combined with tramadol group(Ⅱ group). The PCA pump was started according to the need of patients.The efficacy was evaluated by both PAR(pain relief) and TOTPAR(total pain relief)

coagulation、transplatation renal survival rate and adverse reactions were also observed.Results:No significant statistical difference in both PAR and TOTPAR as well as renal function were observed between the 2groups

but lornoxicam has less adverse effects.Conclusion:The analgesia effect of Ⅱ group used in PCA for renal transplatation comparable to that of I group but Ⅱ group with less adverse effects.

关键词

氯诺昔康术后镇痛患者自控镇痛肾移植

Keywords

Lornoxicampostoperative analgesiaPatient-controlled analgesiaRenal transplatation

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