Expression of survivin,P16<sup>INK4a</sup> in non-small cell lung carcinoma and their significance

HAN Xiaoli; et al

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Expression of survivin,P16^INK4a in non-small cell lung carcinoma and their significance

更新时间：2024-01-17

- Expression of survivin,P16^INK4a in non-small cell lung carcinoma and their significance
- Journal of Chongqing Medical University Issue 3, Pages: 264-267(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院呼吸内科
  2. 重庆医科大学附属第一医院呼吸内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2
- Published：2007，
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[1]韩晓黎,江涛.Survivin、P16~(INK4a)在非小细胞肺癌中的表达及意义[J].重庆医科大学学报,2007(03):264-267+270.

HAN Xiaoli, et al. Expression of survivin,P16^INK4a in non-small cell lung carcinoma and their significance. [J]. Journal of Chongqing Medical University (3):264-267(2007)
[1]韩晓黎,江涛.Survivin、P16~(INK4a)在非小细胞肺癌中的表达及意义[J].重庆医科大学学报,2007(03):264-267+270. DOI：

HAN Xiaoli, et al. Expression of survivin,P16^INK4a in non-small cell lung carcinoma and their significance. [J]. Journal of Chongqing Medical University (3):264-267(2007) DOI：

摘要

目的:探讨新的凋亡抑制基因survivin在非小细胞肺癌（Non-small cell lung carcinoma

NSCLC）中的表达

及其与抑癌基因P16INK4a表达的相关性。方法:用免疫组化的方法检测survivin和P16INK4a在56例NSCLC组织中的表达

同时抽取12例非肺癌的肺部良性病变手术标本作为对照组。结果:NSCLC组织中survivin阳性率64.3%、明显高于肺良性病变组织（8.3%）（P<0.01）

P16INK4a在NSCLC组织和肺良性病变组织中的失表达率分别为51.8%、16.7%（P<0.01）。NSCLC组织中survivin阳性率和P16INK4a失表达率均与NSCLC的病理分级、临床分期和淋巴结转移密切相关（P<0.01）。Survivin在NSCLC组织中P16INK4a表达阳性和阴性病例

阳性率分别为40.8%（11/27）和86.2%（25/29）（P<0.01）

且表达呈负相关（r=-0.459

P<0.01）。结论:在NSCLC中survivin的过表达和P16INK4a的失表达提示二者可能通过抑制细胞凋亡和促进细胞增殖在非小细胞肺癌的发生发展中起协同作用

同时检测survivin、P16INK4a的表达状态对非小细胞肺癌的诊断和预后有一定的参考价值。

Abstract

Objective:To study the expression of a novel apoptosis inhibitor gene

survivin

in non-small cell lung carcinoma (NSCLC)

and its correlation to the expression of P16INK4a gene.Methods:The immunohistochemistry was used to assay the expression of surviving and P16INK4a in tissues of fifty-six cases of non-small cell lung carcinoma

with 12 specimens of benign lesions as the control.Results:Survivin was expressed in 36 out of 56(64.3%)cases of NSCLC

and its expression rate in benign pulmonary diseases was only 8.3%(P<0.01).The negative P16INK4a protein expression rates in NSCLC tissues and benign impaired tissues were 51.8% and 16.7% respectively.Overexpression of survivin and negative expressionof P16INK4a in NSCLC were strongly related to the tumor grade

clinical TNM stages and lymph node metatstasis(P<0.01).In P16INK4a positive expression group and negative expression group

the positive rates of survivin expression were 40.8%(11/27)and 86.2%(25/29)respectively.The difference was significant(P<0.01)and the expressions of survivin and P16INK4a showed a reuerse correlation(r=-0.459

P<0.01).Conclusion:Overexpression of survivin and negative expression of P16INK4a in NSCLC indicated survivin and P16INK4a may play cooperative role in the tumorigenesis and development of NSCLC through inhibiting cancer cell apoptosis and promoting proliferation.So the expressions of Survivin and P16INK4a can be used as references for the diagnosis and prognosis of NSCLC.

关键词

Survivinp16INK4a非小细胞肺癌免疫组化

Keywords

Survivinp16INK4aNon-small cell lung carcinoma(NSCLC)immunohistochemistry

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Expression of survivin,P16INK4a in non-small cell lung carcinoma and their significance

DOI：

摘要

Abstract

关键词

Keywords

references

Expression of survivin,P16^INK4a in non-small cell lung carcinoma and their significance