The application of five serum markers in therapeutic effectiveness evaluation with breast cancer

GAO Han; et al

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The application of five serum markers in therapeutic effectiveness evaluation with breast cancer

更新时间：2024-01-17

- The application of five serum markers in therapeutic effectiveness evaluation with breast cancer
- Journal of Chongqing Medical University Issue 6, Pages: 623-625(2007)
- 作者机构：
  
  1. 第三军医大学附属西南医院乳腺中心
  2. 第三军医大学附属西南医院乳腺中心,重庆,400038
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2007，
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[1]高寒,姜军,杨新华,范林军,谢竟.五种血清标志物在乳腺癌疗效评价中的应用[J].重庆医科大学学报,2007(06):623-625.

GAO Han, et al. The application of five serum markers in therapeutic effectiveness evaluation with breast cancer. [J]. Journal of Chongqing Medical University (6):623-625(2007)
[1]高寒,姜军,杨新华,范林军,谢竟.五种血清标志物在乳腺癌疗效评价中的应用[J].重庆医科大学学报,2007(06):623-625. DOI：

GAO Han, et al. The application of five serum markers in therapeutic effectiveness evaluation with breast cancer. [J]. Journal of Chongqing Medical University (6):623-625(2007) DOI：

摘要

目的:探讨血清标志物CA15-3、CA125、CEA、CYFRA21-1和TPS在乳腺癌新辅助化疗前、后检测值的变化

筛选评价乳腺癌化疗效果较好的标志物。方法:采用ELISA法测定48例乳腺癌患者化疗前及经新辅助化疗后的血清CA15-3、CA125、CEA、CYFRA21-1和TPS的检测值。结果:在化疗有效组患者血清中

化疗前、后CA15-3、CEA和CYFRA21-1的检测值显著降低（P<0.05）

在化疗无效组患者血清中

CA15-3、CA125、CEA、CYFRA21-1和TPS的检测值无显著变化（P>0.05）

经logistic多因素回归分析

CA15-3、CYFRA21-1和CEA可作为评价乳腺癌化疗疗效的指标

其评价作用由强到弱依次降低。结论:血清中CA15-3、CYFRA21-1和CEA在评价乳腺癌化疗效果中均有一定价值

而CA15-3价值更大。

Abstract

Objective:To approach the change of five serum markers such as CA15-3、CA125、CEA、CYFRA21-1 and TPS with breast cancer between pre-and post-neoadjuvant chemotherapy

to screen the better treatment effectiveness evaluation markers.Methods:The serum markers such as CA15-3、CA125、CEA、CYFRA21-1 and TPS of 48 cases with breast cancer were detected by enzyme linked immunosorbent assay respectively pre-and post-neoadjuvant chemotherapy.Results:In effective group

CA15-3、CYFRA21-1 and CEA were significantly decreased(P<0.05)

but in ineffective group

CA15-3、CA125、CEA、CYFRA21-1 and TPS had no obviously change(P>0.05).Through Logistic multiple factor regression analysis

CA15-3?CYFRA21-1and CEA were the better markers of among the five markers to evaluate the neoadjuvant chemotherapy efficacy of breast cancer

and evaluate role from strong to poor by turns.Conclusion:CA15-3 was the best marker of five serum markers to evaluate the neoadjuvant chemotherapy efficacy of breast cancer.

关键词

标志物乳腺癌

Keywords

markersbreast cancer

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