Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication

LI Henghua; et al

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Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication

更新时间：2024-01-17

- Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication
- Journal of Chongqing Medical University Issue 6, Pages: 619-622(2007)
- 作者机构：
  
  1. 重庆医科大学药理教研室
  2. 重庆医科大学药理教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R749.16
- Published：2007，
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[1]李恒华,孙峰,刘颖菊,高丽佳.高胆固醇血症促进淀粉样蛋白在铝中毒小鼠脑内沉积[J].重庆医科大学学报,2007(06):619-622.

LI Henghua, et al. Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication. [J]. Journal of Chongqing Medical University (6):619-622(2007)
[1]李恒华,孙峰,刘颖菊,高丽佳.高胆固醇血症促进淀粉样蛋白在铝中毒小鼠脑内沉积[J].重庆医科大学学报,2007(06):619-622. DOI：

LI Henghua, et al. Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication. [J]. Journal of Chongqing Medical University (6):619-622(2007) DOI：

摘要

目的:观察高胆固醇血症对铝中毒致小鼠神经元损伤的促进作用。方法:小鼠给予铝400mg（/kg.d）连续灌胃10周

实验第3周起改饲高胆固醇饮食至第10周末。结果:铝中毒组和铝中毒联合高胆固醇饮食组小鼠空间识别能力明显减退（P<0.05）

海马CA1、CA2区神经元明显损伤。与单纯铝中毒组相比

铝中毒联合高胆固醇饮食组血清总胆固醇明显升高（P<0.05）

小鼠空间识别能力下降程度和海马神经元损伤更明显

刚果红染色显示海马神经元损伤区出现淀粉样蛋白沉淀。结论:高胆固醇血症能加重铝中毒导致的神经元损伤

其机制可能跟促进淀粉样蛋白沉积有关。

Abstract

Objective:To investigate the aggravating effects of hypercholesterolemia on the damage to neurons induced by aluminum intoxication in mice.Methods:Aluminum was given by gavage with Al 400 mg/(kg.d) for 10 weeks.Mice were placed on high-cholesterol diet the third week after Al was given.Results:The spatial recognition ability decreased significantly(P<0.05) and hippocampal neurons(CA1

CA2)were damaged obviously in mice with aluminum and with or without high-cholesterol diet

compared with control group with basal diet.Moreover

the impairment of spatial recognition ability and the damage to neurons were more serious and pathological changes of amyloid in the hippocampus(CA1

CA2)with CR staining were found in mice with aluminum and high-cholesterol diet.Conclusions:Hypercholesterolemia may aggravate the damage to neurons induced by aluminum intoxication and its mechanisms might involve the acceleration of the amyloid deposition.

关键词

高胆固醇血症淀粉样蛋白铝

Keywords

hypercholesterolemiaAmyloidAluminum

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