Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis

CHEN Yikuan; et al

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Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis

更新时间：2024-01-17

- Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis
- Journal of Chongqing Medical University Issue 6, Pages: 626-628(2007)
- 作者机构：
  
  1. 重庆医科大学附属第二医院普外科
  2. 重庆医科大学附属第二医院普外科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC： R363
- Published：2007，
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[1]陈以宽,龚建平,罗文军,孙建民.骨髓干细胞动员在深静脉血栓溶解中的作用[J].重庆医科大学学报,2007(06):626-628.

CHEN Yikuan, et al. Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis. [J]. Journal of Chongqing Medical University (6):626-628(2007)
[1]陈以宽,龚建平,罗文军,孙建民.骨髓干细胞动员在深静脉血栓溶解中的作用[J].重庆医科大学学报,2007(06):626-628. DOI：

CHEN Yikuan, et al. Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis. [J]. Journal of Chongqing Medical University (6):626-628(2007) DOI：

摘要

目的:探讨骨髓干细胞动员在深静脉血栓溶解中的作用。方法:SD成年大鼠随机分为正常组、假手术组、手术组、动员组（使用rhG-CSF皮下注射）。分析不同时点外周血单个核细胞计数、病理组织形态、血栓机化率的变化。结果:动员组外周血单个核细胞计数明显升高

其余各组无明显变化。与手术组比较

术后第7天动员组静脉血栓内炎性细胞数量明显增多

第14天

血栓的机化范围更广

血栓机化率有显著性差异。结论:骨髓干细胞动员促进了血栓的溶解、吸收过程。

Abstract

Objective:To explore the effect of bone marrow stem cell mobilization in resolution of deep vein thrombosis.Methods:The SD adult rats were randomly divided into normal

sham

surgical and mobilization group(with subcutaneous injection of rhG-CSF).The peripheral blood mononuclear cell count

pathological change and thrombus organization rate in different time were examined.Results:The peripheral blood mononuclear cell count in mobilization group was significantly elevated

and there was no significant change in other groups.Compared with surgical group

there were more inflammatory cells in thrombus of mobilization group at 7th postoperative day

and the organization area of thrombus was wider and the organization rate was significantly different in mobilization group at 14th postoperative day(P<0.05).Conclusion:The bone marrow stem cell mobilization contribute to the resolution of deep vein thrombosis.

关键词

深静脉血栓骨髓干细胞动员集落刺激因子

Keywords

deep vein thrombosisBone marrow stem cell mobilizationColony-stimulating factor

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