Investigation of the stability of adriamycin liposome by TLC

ZHAO Jun-yi; et al

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Investigation of the stability of adriamycin liposome by TLC

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- Investigation of the stability of adriamycin liposome by TLC
- Journal of Chongqing Medical University Issue 9, Pages: 1096-1098(2008)
- 作者机构：
  
  重庆医科大学药学院药剂教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R927.11
- Published：2008，
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[1]赵俊义,朱莉,胡春梅,潘黎军,王驰.TLC法考察阿霉素脂质体的稳定性[J].重庆医科大学学报,2008(09):1096-1098+1102.

ZHAO Jun-yi, et al. Investigation of the stability of adriamycin liposome by TLC. [J]. Journal of Chongqing Medical University (9):1096-1098(2008)
[1]赵俊义,朱莉,胡春梅,潘黎军,王驰.TLC法考察阿霉素脂质体的稳定性[J].重庆医科大学学报,2008(09):1096-1098+1102. DOI：

ZHAO Jun-yi, et al. Investigation of the stability of adriamycin liposome by TLC. [J]. Journal of Chongqing Medical University (9):1096-1098(2008) DOI：

摘要

目的:通过以TLC分离阿霉素脂质体各组分及其降解产物

考察其作为阿霉素脂质体稳定性评价方法的适用性以及进行方法改进。方法:分别用4种TLC展开系统进行2次展开

用4-甲氧基苯甲醛显色。结果:以氯仿-甲醇-水-氨水（65∶35∶2.5∶2.5）作展开剂

分离效果较好。结论:TLC法操作简便、重复性好

可用作脂质体质量控制的一种方法。

Abstract

Objective:To investigate the usability of TLC as a evaluating method for adriamycin liposome stability by separating its composition and degradation products with TLC and improve this method. Methods:The plates were developed twice with four development systems

visualized by 4-methoxybenzaldehyde. Results:It was better to separate EPC

cholesterol and their degradation products by using chloroform-methanol-water-ammonia(65∶35∶2.5∶2.5) as the mobile phase. Conclusion:TLC could be used for the quality control of the adriamycin liposome due to its simple operation and high reproducibility.

关键词

脂质体TLC阿霉素稳定性双展开法

Keywords

liposomeTLCAdriamycinstabilityDouble-development Method

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