The single itraconazole and combination with interferon-γ against candida albicans infection

LIAO Xiao-rong; et al

您当前的位置：

首页 >

文章列表页 >

The single itraconazole and combination with interferon-γ against candida albicans infection

更新时间：2024-01-17

- The single itraconazole and combination with interferon-γ against candida albicans infection
- Journal of Chongqing Medical University Issue 9, Pages: 1092-1095(2008)
- 作者机构：
  
  重庆医科大学附属第一医院皮肤科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R965
- Published：2008，
扫描看全文
[1]廖晓容,高永良,周汛.单用伊曲康唑及联合γ-干扰素对小鼠白假丝酵母菌感染抗菌作用的实验研究[J].重庆医科大学学报,2008(09):1092-1095.

LIAO Xiao-rong, et al. The single itraconazole and combination with interferon-γ against candida albicans infection. [J]. Journal of Chongqing Medical University (9):1092-1095(2008)
[1]廖晓容,高永良,周汛.单用伊曲康唑及联合γ-干扰素对小鼠白假丝酵母菌感染抗菌作用的实验研究[J].重庆医科大学学报,2008(09):1092-1095. DOI：

LIAO Xiao-rong, et al. The single itraconazole and combination with interferon-γ against candida albicans infection. [J]. Journal of Chongqing Medical University (9):1092-1095(2008) DOI：

摘要

目的:研究单用伊曲康唑（Itraconazole）及联合γ-干扰素（IFN-γ）对小鼠白假丝酵母菌感染的抗菌作用。方法:制备系统性白假丝酵母菌感染小鼠模型

单用不同剂量伊曲康唑及联合γ-干扰素治疗感染小鼠。取肝、肾组织培养及组织切片

通过计数菌落形成单位（CFU）及组织病理切片情况

判定单用伊曲康唑及联合γ-干扰素抗白假丝酵母菌感染的作用。结果:伊曲康唑10mg/kg与105Uγ-干扰素联合应用白假丝酵母菌感染有较好的协同作用

而伊曲康唑50mg/kg与105Uγ-干扰素联合应用其协同疗效不显著。50mg/kg伊曲康唑组单用有很好的抗白假丝酵母菌作用。结论:小剂量的伊曲康唑与γ-干扰素联合应用对小鼠系统性白假丝酵母菌感染有较好的协同作用。大剂量伊曲康唑单用也有很好的抗菌原理。

Abstract

Objective:To study the efficacy of single itraconazole and combination with interferon-γ against Candida albicans infection.Methods:Murine models of systemic candida albicans infection were established

and treated with different concentrations of itraconazol alone and combination with INF-γ. Then the concentrations of colonyforming units(cfu) and histolo gical sections were observed to evaluate the emcacy. Results:The combination of 105U INF-γ and itraconazole at the dosage of 10mg/kg showed better effect against Candida albicans than the combination of itraconazole at the dosage of 50mg/kg with 105U INF-γ. Conclusion:The combination of itraconazole at a low dose with INF-γ shows a good effect against Candida albicans.The single use of itraconazole at a high dose is also anti-infection.

关键词

白假丝酵母菌伊曲康唑γ-干扰素菌落形成单位

Keywords

Candida albicansLtraconazolInterferon-γColony forming units(CFU)

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Inhibiting effect of CHR on biofilm formation of Candida albicans and its mechanism

The significance of detecting interferon-γ,adenosine deaminase and neopterin in the diagnosis of tuberculous pleural effusion

Related Author

Zhang Shu

Xu Shan

Zhang Dan

Huang Wenxiang

Wei Fu

Liu Siyi

Luo Shengshu

He Qin

Related Institution

Department of Hepatic Surgery,The First Affiliated Hospital of Chongqing Medical University

Department of Intensive Medicine,The First Affiliated Hospital of Chongqing Medical University

Laboratory of Etiology on Infectious Disease,The First Affiliated Hospital of Chongqing Medical University

Department of Laboratory Instrument,Faculty of Laboratory,Chongqing Medical University

⁰