Preliminary study of the destructive characteristics of the liver induce by focused ultrasound surgical clamp

MIAO Ji-dong; et al

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Preliminary study of the destructive characteristics of the liver induce by focused ultrasound surgical clamp

更新时间：2024-01-17

- Preliminary study of the destructive characteristics of the liver induce by focused ultrasound surgical clamp
- Journal of Chongqing Medical University Issue 8, Pages: 903-906(2008)
- 作者机构：
  
  1. 重庆医科大学生物医学工程系医学超声工程研究所
  2. 重庆医科大学附属第一医院肝胆外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.7
- Published：2008，
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[1]缪继东,赵毅,胡晓东,赵纯亮,王济明,伍烽.聚焦超声手术钳对肝脏损伤模式的初步研究[J].重庆医科大学学报,2008(08):903-906.

MIAO Ji-dong, et al. Preliminary study of the destructive characteristics of the liver induce by focused ultrasound surgical clamp. [J]. Journal of Chongqing Medical University (8):903-906(2008)
[1]缪继东,赵毅,胡晓东,赵纯亮,王济明,伍烽.聚焦超声手术钳对肝脏损伤模式的初步研究[J].重庆医科大学学报,2008(08):903-906. DOI：

MIAO Ji-dong, et al. Preliminary study of the destructive characteristics of the liver induce by focused ultrasound surgical clamp. [J]. Journal of Chongqing Medical University (8):903-906(2008) DOI：

摘要

目的:观察聚焦超声手术钳（Focused ultrasound surgical clamp

FUSC）对离体肝脏的损伤模式。方法:FUSC由固定钳状手柄上

中轴线重合

能产生2束方向相对应的聚焦超声波的2个超声换能器构成。在超声频率为1.6MHz

声强（ISPPA）12000W/cm2条件下

对厚度4～10cm离体牛肝进行双面连续扫描辐照后

记录牛肝达到贯通性凝固性坏死的辐照时间

测量离体牛肝凝固性坏死性状的形状和特征

观察组织病理学的变化。结果:FUSC对所有厚度的肝组织均能造成贯通的凝固性坏死。凝固性坏死的形状与FUSC的声场形态基本一致

长度为2.72～3.20cm

宽为1.44～1.80cm。在相同声功率下

随着牛肝厚度增加

造成靶区贯通性凝固性坏死的时间随之增加。结论:FUSC对离体牛肝进行辐照

能造成预定靶区肝组织的贯通性凝固性坏死。本实验为肝切除术提供了一种新的手术器械。

Abstract

Objective:To observe the destructive characteristics of the bovine liver induced by focused ultrasound clamp technique.Methods:A focused ultrasound surgical clamp(FUSC) consisted of two transducers fixed on a forceps-like handle.The directions of focused ultrasound beams were opposite

with the same central axes.The thickness of bovine liver in vitro ranged from 4 to 10cm.Ultrasound energy was continuously delivered to ablate the liver with a frequency of 1.6MHz

and spatial peak pulse average acoustic intensity(ISPPA) of 12 000W/cm2.The characteristics of complete coagulation necrosis and exposure time were measured after FUSC exposure

and pathological changes in treated bovine liver tissue were observed.Results:FUSC induced complete coagulation necrosis of predetermined bovine liver targets.The shape of coagulation necrosis was corresponded with focused ultrasound beam

with 2.72～3.20cm in length and 1.44～1.80cm in width.However

under the same exposure energy

exposure time for complete necrosis increased

as the thickness of the liver increased.Conclusion:FUSC can induce complete coagulation necrosis of predetermined bovine liver targets.This study would provide a novel surgical instrument for hepatectomy.

关键词

聚焦超声肝切除出血肝癌

Keywords

focused ultrasoundhepatectomybleedinghepatocellular carcinoma

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Related Institution

重庆医科大学生物医学工程系医学超声工程研究所

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