Histopathological change of the fragrant pig skin induceced by focus ultrasound repetition irradiation

XIAO Qing; et al

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Histopathological change of the fragrant pig skin induceced by focus ultrasound repetition irradiation

更新时间：2024-01-17

- Histopathological change of the fragrant pig skin induceced by focus ultrasound repetition irradiation
- Journal of Chongqing Medical University Issue 8, Pages: 900-902(2008)
- 作者机构：
  
  重庆医科大学医学超声工程研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R312
- Published：2008，
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[1]肖青,王智彪,李发琪,陈容.聚焦超声对香猪皮肤重复损伤的组织病理学变化的研究[J].重庆医科大学学报,2008(08):900-902.

XIAO Qing, et al. Histopathological change of the fragrant pig skin induceced by focus ultrasound repetition irradiation. [J]. Journal of Chongqing Medical University (8):900-902(2008)
[1]肖青,王智彪,李发琪,陈容.聚焦超声对香猪皮肤重复损伤的组织病理学变化的研究[J].重庆医科大学学报,2008(08):900-902. DOI：

XIAO Qing, et al. Histopathological change of the fragrant pig skin induceced by focus ultrasound repetition irradiation. [J]. Journal of Chongqing Medical University (8):900-902(2008) DOI：

摘要

目的:探讨聚焦超声对香猪皮肤重复损伤的组织病理学变化

为临床重复治疗带状疱疹后遗神经痛（Postherpetic neuralgia

PHN）的安全性和有效性提供实验依据。方法:功率2W

频率10.06MHz的参数下对香猪皮肤进行不重复连续直线辐照

隔日相同的条件下再次辐照

共3次

光电镜下观察皮肤变化的情况。结果:肉眼可见皮肤充血水肿明显;光镜下可见皮肤真皮层充血水肿

毛细血管扩张增生

炎症细胞侵润

均未见凝固性坏死;电镜下血管内皮细胞线粒体肿胀

微吞饮小泡数量多

成纤维细胞线粒体肿胀

粗面内质网扩张

神经纤维内线粒体肿胀。结论:（1）此剂量下的超声可对皮肤真皮层造成可逆性损伤。（2）一定剂量一定时间间隔的重复辐照不会引起皮肤的积累损伤

说明超声用于PHN的重复治疗是安全的。

Abstract

Objective:To explore the histopathological change of the fragrant pig skin induced by focus ultrasound repetition irradiation to offer experiment basis for the safety and effectivessness of clinically treating postherpetic neuralgia(PHN) by repetition irradiation.Methods:The pig skin was irradiated once every other day

altogether three

with irradiation power as 2W

and frequency as 10.06MHz

The skin change was observed under light microscope and electron microscope.Results:Hyperemia and edema in irradiation area after irradiation were observed instantly to the eye;Under light microscope there were hyperemia and edema in epidermis

angiotelectasis and inflammatory infiltrating

and find coagulative necrosis in slice was not observed.Under electron microscope

instantly after ultrasound irradiation every other day

endothelial cell of blood vessel can be found mitochondria swelling and more micropinocytotic vesicles

mitochondria swelling and rough endoplasmic reticulum dilatation were noted for in fibroblasts

and mitochondfia swelling for nerve fibre.Conclusions:(1)There is reversibile lesion in epidermis under this dose of ultrasound.(2)Skins don’t accumulate lesion every other day after irradiation repeatly .which illustrates that it is effective and safe to treat postherpetic neuralgia by ultrasound irradiation repeatly.

关键词

超声重复带状疱疹后遗神经痛

Keywords

ultrasoundRepetitionPostherpetic neuralgia

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