A case-control study on the role of calpainl0 gene single nucleotide polymorphism in the genetic susceptibility to type 2 diabetes mellitus in southern Chinese Han population

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A case-control study on the role of calpainl0 gene single nucleotide polymorphism in the genetic susceptibility to type 2 diabetes mellitus in southern Chinese Han population

更新时间：2024-01-17

- A case-control study on the role of calpainl0 gene single nucleotide polymorphism in the genetic susceptibility to type 2 diabetes mellitus in southern Chinese Han population
- Journal of Chongqing Medical University Vol. 33, Issue 12, Pages: 1475-1478(2008)
- 作者机构：
  
  重庆医科大学基础医学院细胞生物学及遗传学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2008，
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[1]董靖,彭惠民.CAPN10基因单核苷酸多态性与西南地区人群2型糖尿病的相关性研究[J].重庆医科大学学报,2008,33(12):1475-1478.

A case-control study on the role of calpainl0 gene single nucleotide polymorphism in the genetic susceptibility to type 2 diabetes mellitus in southern Chinese Han population. [J]. Journal of Chongqing Medical University 33(12):1475-1478(2008)
[1]董靖,彭惠民.CAPN10基因单核苷酸多态性与西南地区人群2型糖尿病的相关性研究[J].重庆医科大学学报,2008,33(12):1475-1478. DOI：

A case-control study on the role of calpainl0 gene single nucleotide polymorphism in the genetic susceptibility to type 2 diabetes mellitus in southern Chinese Han population. [J]. Journal of Chongqing Medical University 33(12):1475-1478(2008) DOI：

摘要

目的:探讨calpain10基因单核苷酸多态性（Single nucleotide polymorphism

SNP）与西南地区汉族人群2型糖尿病（Type2diabetes mellitus

T2DM）遗传易感性的关系。方法:采用病例-对照研究设计

对144例T2DM患者和98例正常对照者采用双向等位特异性PCR技术（Bi-PASA）

检测calpain10基因SNP43A/G位点、SNP44C/T位点和SNP56A/G位点的基因型

并进行关联分析。结果:与对照组相比

病例组SNP43的G/G等位基因型频率、SNP44的C/T等位基因型频率和SNP56的A/A等位基因型频率显著升高（分别为86.11%

73.5%;36.8%

19.36%;38.0%

9.8%）。SNP43的G等位基因频率、SNP44的C等位基因频率和SNP56的A等位基因频率在西南地区T2DM人群中显著升高（分别为93.06%

86.22;19.1%

9.69%;60.07%

44.96%）;单体型ATG、GCA、GTG频率在病例组与对照组的分布具有显著差异。结论:calpain10基因可能为西南地区汉族人群T2DM的易感基因。

Abstract

Objective:To test the hypothesis that calpain10 gene could contribute to the genetic susceptibility to type 2 diabetes mellitus(T2DM)in southern Chinese Han population.Methods:In this case-control study

Bi-PASA method was used to determine the distribution of allele and genotype frequencies of SNP43 polymorphism(A/G)

SNP44 polymorphism(C/T)and SNP56 polymorphism(A/G)in Calpainl0 in 144 type2 diabetes patients and 98 normal control subjects.Results:The genotypes frequencies of SNP43 G/G

SNP44 C/T and SNP56 A/A were significant increased in case group

as compared with the control group(86.11% vs 73.5%;36.8% vs 19.36 %;38.0% vs 9.8%

respectively).The frequencies of SNP43 G-allele

SNP44 C-allele and SNP56 A-allele in T2DM patients were significantly increased as compared with that in the control subjects(93.06% vs 86.22;19.1% vs 9.69% ;60.07%

44.96% respectively);The haplotype frequencies of ATG、GCA and GGT were significanty different between T2DM patients and control subjects.Conclusion:The study suggested that Calpainl0 gene might contribute to the genetic susceptibility to T2DM in southern Chinese Han population。

关键词

calpain102型糖尿病遗传易感性单核甘酸多态性

Keywords

Calpain10 genetype 2 diabetes mellitusgenetic susceptibilitySingle nucleotide polymorphism(SNP)

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