Objective:To study the effects of Probucol and Fosinopril on liver histological changes in type 2 diabetes mellitus. Methods: Male Wistar rats

weighing 140～160 g

were fed with chowdiet for one week

and then randomly divided into two groups:the control group (C

twelve rats)was fed with chowdiet

while another group(thirty-six rats)was fed with high-fat diet. The rats in high-fat diet group were successfully established as type 2 diabetes model four weeks later (fasting serum glucose≥7.8 mmol/l)through streptozocin (STZ)(35 mg/kg)intraperitoneal injecting

then randomly divided into three groups (twelve rats each group):Rats in Probucol group were fed with high-fat diet and Probuco(l500 mg(/kg·d)

lavage);Rats in Fosinopril group were fed with high-fat diet and Fosinopri(l5.0 mg(/kg·d)

lavage);Rats in simple high-fat diet group were fed with high-fat diet and water(2 ml(/one·d)

lavage). Six weeks later

ratio of liver to body weight

serum ALT

AST

TG

TCHO

HDL

MDA and SOD activity

histological scoring for Nonalcoholic fatty liver disease(NAFLD) were measured respectively. Results:TCHO and ALT were significantly reduced by Probucol treatment compared with HD group (P<0.05

P<0.05)

while HDLlevel and SODactivitywere elevated(P<0.05

P<0.001). SerumALTwas significantlyreduced(P<0.01)

whereas HDL level and SOD activity were elevated by Fosinopril treatment (P<0.05

P<0.001). Fosinopril had no effect on TG and TCHO. Liver weight/Body weight was reduced by Probucol treatment (P<0.05)

but aggravated by Fosinopril treatment(P<0.001) compared with HD group. Liver lobular inflammation score was lessened in Probucol and Fosinopril treated groups. Conclusion:Probucolcan improve liver inflammation by decreasing TCHO level and oxidative stress. And Fosinopril can improve liver inflammation only by decreasing oxidative stress

while no effect on TCHO. Hepatomegaly was reduced by Probucol treatment

but aggravated by Fosinopril treatment.The adverse effect of Fosinopril on aggravating hepatomegaly should be furtherly investigated.