Association between the angiotensin Ⅱ type Ⅰ receptor gene A1166C polymorphism with the essential hypertension in chongqing

XIANG Lin; et al

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Association between the angiotensin Ⅱ type Ⅰ receptor gene A1166C polymorphism with the essential hypertension in chongqing

更新时间：2024-01-17

- Association between the angiotensin Ⅱ type Ⅰ receptor gene A1166C polymorphism with the essential hypertension in chongqing
- Journal of Chongqing Medical University Vol. 34, Issue 4, Pages: 435-438(2009)
- 作者机构：
  
  重庆医科大学附属第一医院临床研究中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R544.1
- Published：2009，
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[1]向林,柳青,雷寒.AT1R基因A1166C多态性与重庆地区高血压病的相关性研究[J].重庆医科大学学报,2009,34(04):435-438.

XIANG Lin, et al. Association between the angiotensin Ⅱ type Ⅰ receptor gene A1166C polymorphism with the essential hypertension in chongqing. [J]. Journal of Chongqing Medical University 34(4):435-438(2009)
[1]向林,柳青,雷寒.AT1R基因A1166C多态性与重庆地区高血压病的相关性研究[J].重庆医科大学学报,2009,34(04):435-438. DOI：

XIANG Lin, et al. Association between the angiotensin Ⅱ type Ⅰ receptor gene A1166C polymorphism with the essential hypertension in chongqing. [J]. Journal of Chongqing Medical University 34(4):435-438(2009) DOI：

摘要

目的:研究重庆地区人口血管紧张素Ⅱ的Ⅰ型受体（AngiotensinⅡtypeⅠ

AT1R）A1166C基因多态性与原发性高血压的关系方法:用多聚酶联反应（Polymerase chain reaction

PCR）结合限制性片段长度多态性（Restriction fragment length polymor-phism

RFLP）方法对104例原发性高血压（Essentiac hypertension

EH）患者和100例健康体检者进行AT1R（A1166C）的基因多态性分析。结果:EH组AC基因型频率明显高于正常对照组（0.240vs0.005

P<0.05）

EH组C1166等位基因频率明显高于正常对照组（0.130vs0.025

P<0.05）;而EH组中的AA基因型频率明显低于正常对照组（0.750vs0.950

P<0.05）;EH组中还发现了较罕见的CC纯合子基因型。结论:高血压组和正常对照组AT1R基因的AC、AA基因型频率有显著性差异

而其它指标无显著性差异。重庆地区原发性高血压与AT1R基因的A1166C多态性有密切的关系。

Abstract

Objective:To study the relationship of the angiotensinⅡtypeⅠreceptor(AT1R)gene polymorphisms with the essential hy-pertension(EH)in Chongqing.Methods:The AT1R gene polymorphism(an A→C transversion at nucleotide position1166)were detected by polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)in 104 EH patients and 100 normal controls.Results:The frequencies of AC genotype and C1166 allele of AT1R gene of the EH patients were obviously higher than those of the normal controls(AC genotype:0.240 vs 0.005

P<0.05;Callele:0.130 vs 0.025

P<0.05)

There were both having significance difference

but the frequency of the AA genotype was obviously lower than the normal controls.Furthermore

we discovered infrequent CC genotype in EH patients.The items of rest have no significative difference in two groups.Conclusion:A1166C polymorphism of AT1R gene was associated with essential hypertension in Chongqing.

关键词

原发性高血压血管紧张素Ⅱ-Ⅰ型受体基因多态性

Keywords

essential hypertensionAngiotensin Ⅱ typeⅠreceptorgene polymorphism

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