Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing

LI Xiu-lan; et al

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Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing

更新时间：2024-01-17

- Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing
- Journal of Chongqing Medical University Vol. 34, Issue 4, Pages: 432-435(2009)
- 作者机构：
  
  1. 重庆医科大学附属第一医院临床研究中心
  2. 重庆医科大学附属第一医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R736.6
- Published：2009，
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[1]李秀兰,柳青,吴小候.散发性嗜铬细胞瘤与SDHD基因突变关系研究[J].重庆医科大学学报,2009,34(04):432-435.

LI Xiu-lan, et al. Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing. [J]. Journal of Chongqing Medical University 34(4):432-435(2009)
[1]李秀兰,柳青,吴小候.散发性嗜铬细胞瘤与SDHD基因突变关系研究[J].重庆医科大学学报,2009,34(04):432-435. DOI：

LI Xiu-lan, et al. Study on the mutations of SDHD gene in sporadic pheochromocytoma in Chongqing. [J]. Journal of Chongqing Medical University 34(4):432-435(2009) DOI：

摘要

目的:了解重庆地区散发性嗜铬细胞瘤（Pheochromocytoma

PHEO）与琥珀酸脱氢酶复合物DⅡ单位（Succtnate dehydro-genaes complex

subunitD

SDHD）基因第1、2外显子突变的关系。方法:采用多聚酶联反应结合单链构像多态性分析（Polymerase chain reaction-single strand conformation polymorphism

PCR-SSCP）对32例病理确诊的散发性PHEO患者（其中21例为肾上PHEO

11例为肾上腺外PHEO即副神经节瘤）和80例健康体检者对SDHD基因1、2外显子进行突变分析。结果:32例嗜铬细胞瘤患者中未发现SDHD基因第1、2外显子的突变。结论:在本研究中未发现重庆地区散发PHEO存在SDHD基因第1、2外显子的突变。

Abstract

Objective:To study the association between mutations in the first and second exons of(Succtnate dehydrogenaes complex

subunit D(SDHD)gene and sporadic pheochromocytoma in Chongqing Methods:Polymerase chain reaction combining with single strand conformation polymorphism(PCR-SSCP)was selected to analysis the mutations in the first and second exons of SDHD gene in 32 cases of sporadic pheochromocytoma who were diagnosed by pathology(including 21 cases of pheochromocytoma and 11 cases of extra-adrenal paraganglioma)and 80 cases of the healthy controls.Results:No mutation was found in the first and second exons of SDHD gene in the 32 patients.Conclusion:In our study

we had not found any mutation in the first and second exons of SDHD gene in sporadic pheochromo-cytoma in Chongqing.

关键词

嗜铬细胞瘤PHEO副神经节瘤琥珀酸脱氢酶复合物D亚单位Ⅱ突变

Keywords

PheochromocytomaParagangliomaSuccinate dehydrogenase complexsubunit Dmutation

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