The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels

您当前的位置：

首页 >

文章列表页 >

The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels

更新时间：2024-01-17

|

- The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels
- Journal of Chongqing Medical University Vol. 34, Issue 4, Pages: 439-442(2009)
- 作者机构：
  
  重庆医科大学生物医学工程系重庆市生物医学工程学重点实验室重庆市超声医学工程重点实验室-省部共建国家重点实验室培育基地
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.5
- Published：2009，
扫描看全文
[1]秦艳,李全义,王琦,龚晓波,李发琪,白晋.HIFU联合SonoVue损伤含较大血管肝组织的实验研究[J].重庆医科大学学报,2009,34(04):439-442.

QIN Yan, et al. The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels. [J]. Journal of Chongqing Medical University 34(4):439-442(2009)
[1]秦艳,李全义,王琦,龚晓波,李发琪,白晋.HIFU联合SonoVue损伤含较大血管肝组织的实验研究[J].重庆医科大学学报,2009,34(04):439-442. DOI：

QIN Yan, et al. The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels. [J]. Journal of Chongqing Medical University 34(4):439-442(2009) DOI：

摘要

目的:探讨HIFU联合SonoVue辐照含有较大血管的靶组织时形成损伤的情况。方法:采用JC型聚焦超声肿瘤治疗系统

对10只南江黄羊正常肝脏进行直线扫描

选择含有3mm血管肝脏组织作为靶区

试验组HIFU辐照前静脉注射SonoVue

对照组不注射SonoVue。于治疗24h后过量麻药处死动物

测量肝脏损伤长、宽以及厚

比较有SonoVue组和无SonoVue组凝固性坏死出现率以及凝固性坏死体积有无差异。结果:损伤深度为30mm

靶组织内含有3mm血管时

HIFU联合SonoVue能够有效的形成损伤

有SonoVue组和无SonoVue组凝固性坏死出现率以及凝固性坏死体积存在差异

差异有统计学意义（P<0.05）。结论:当靶组织内含有较大血管时

SonoVue能够提高HIFU治疗效率

有效的形成损伤。

Abstract

Objective:To study the formation of lesions

caused byHIFU with SonoVue

in liver tissues containing blood vessels with the diameter of about 3mm.Methods:The livers of ten goats were insonicated linearly by Model-JC focused ultrasound tumour therapeutic system.The target regions contained blood vessels with the diameter of about 3mm

with or without SonoVue.24 hours after the insonication

the goats were executed with overdosage anesthetics.The length

width and thickness of the lesions were measured

then the necrosies volumes with and without SonoVue were compared.Results:When the depth was 30mm

and the target regions caotained large blood vessels

HIFU with SonoVue could form lesions effectively.There was difference of necrosis volumes between lesions with and without SonoVue

and the difference was significan(tP<0.05).Conclusions:When the target tissues contain large vessels

SonoVue can in- crease the efficacy of HIFU

and form lesions effectively.

关键词

高强度聚焦超声增效SonoVue血管肝脏

Keywords

high intensity focused ultrasoundIncrease efficacySonoVueBlood vesselsliver

references

0

Views

74

下载量

1

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Related Articles

Effect of irreversible electroporation on the structure of blood vessels of goat livers

Imaging study of MRI-guided high intensity focused ultrasound damage of liver tissues in vitro

Establishment and evaluation of a new method for studying fatty acid uptake in vivo

Dynamic expressions of heme oxygenases in the livers of chronic cerebral hypoperfusion rats

Effects of recombinant BCG-Sj26GST vaccine of schistome on the expression of TNF-α mRNA during the formation of egg granulomas in the liver of mice

Related Author

Liu Ying

Xiong Zhengai

Li Chengxiang

Yao Chenguo

Jiang Rong

SHEN Jie

et al

申俊玲

Related Institution

Laboratory of Stem Cell and Tissue Engineering,Chongqing Medical University

State Key Laboratory of Power Transmission Equipment & System Security and New Technology

Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Chongqing Medical University

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

Institute of Ultrasonic Engineering in Medicine,Chongqing Medical University

⁰