Effect of substance P on sensation afferent function of gastrointestinal tract

DENG Li-jun; et al

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Effect of substance P on sensation afferent function of gastrointestinal tract

更新时间：2024-01-17

- Effect of substance P on sensation afferent function of gastrointestinal tract
- Journal of Chongqing Medical University Vol. 34, Issue 4, Pages: 428-431(2009)
- 作者机构：
  
  重庆医科大学基础医学院生理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R338
- Published：2009，
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[1]邓丽君,李静,陆杰.P物质对胃肠感觉传入功能的影响[J].重庆医科大学学报,2009,34(04):428-431.

DENG Li-jun, et al. Effect of substance P on sensation afferent function of gastrointestinal tract. [J]. Journal of Chongqing Medical University 34(4):428-431(2009)
[1]邓丽君,李静,陆杰.P物质对胃肠感觉传入功能的影响[J].重庆医科大学学报,2009,34(04):428-431. DOI：

DENG Li-jun, et al. Effect of substance P on sensation afferent function of gastrointestinal tract. [J]. Journal of Chongqing Medical University 34(4):428-431(2009) DOI：

摘要

目的:研究P物质对胃肠感觉传入冲动的影响及其机制。方法:将40只SD大鼠分成5组:正常对照组（NS）、SP小剂量组（75ng/kg）、中剂量组（150ng/kg）、大剂量组（300ng/kg）及spantideⅡ+SP组。应用电生理方法

观察各组注射前后膈下迷走神经传入自发放电以及扩胃诱发放电的变化情况。结果:SP中、大剂量组膈下迷走神经传入自发放电均增强（P<0.05）

大剂量组扩胃诱发传入放电减少（P<0.05）;先给予spantideⅡ后再给予SP

SP对膈下迷走神经传入自发放电和胃扩张诱发传入放电的效应均消失。结论:静脉注射SP对膈下迷走神经传入自发放电具有兴奋作用

并表现为剂量依赖性;SP对扩胃诱发传入放电具有抑制作用;这些效应可能均通过神经激呔-1受体NK1受体介导产生。

Abstract

Objective:To study the effect of substance P on sensation afferent of gastrointestinal tract and the corresponding mechanism. Methods:Forty SD rats were divided into 5 groups:control group

low dosage SP group(75 ng/kg)

middle dosage SP group(150ng/kg)

high dosage SP group(300 ng/kg)and spantideII+SP group.The electrophysiological method was used to record the change of spontaneous and gastric distention-induced afferent discharge of subdiaphragmatic vagus nerve in each group.Results:Intravenous SP (150 ng/kg

300 ng/kg)caused significantly increasing effect on the spontaneous afferent discharge(P<0.05)

high dosage SP caused decreasing effect on the gastric distention-induced afferent discharge of subdiaphragmatic vagus nerve(P<0.05).SpantideⅡ+SP significantly inhibited the effect of SP mentioned above.Conclusion:SP elicits excitatory effect on the spontaneous afferent discharge

and the effect may show dose dependent on SP.SP elicits inhibitory effect on gastric-distention induced discharge of subdiaphragmatic vagus nerve.The action of exogenous SP afferent discharge of subdiaphragmatic vagus nerve is possibly mediated by NK1 receptor distributed in the stomach.

关键词

P物质迷走神经神经激呔-1受体胃扩张

Keywords

Substance PVagus nerveNeurokinin-1 receptorGastric distention

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