Effects of caffeic acid phenethyl ester in wnt/β-catenin signaling pathway on human neuroglioma

GUO Chuan; et al

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Effects of caffeic acid phenethyl ester in wnt/β-catenin signaling pathway on human neuroglioma

更新时间：2024-01-17

- Effects of caffeic acid phenethyl ester in wnt/β-catenin signaling pathway on human neuroglioma
- Journal of Chongqing Medical University Vol. 34, Issue 6, Pages: 725-727(2009)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经外科
  2. 重庆医科大学医学检验系临床检验诊断学省部共建教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.4
- Published：2009，
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[1]郭川,唐文渊,钟东,晏怡,姚声涛,刘子杰.CAPE对神经胶质瘤生长抑制作用研究[J].重庆医科大学学报,2009,34(06):725-727.

GUO Chuan, et al. Effects of caffeic acid phenethyl ester in wnt/β-catenin signaling pathway on human neuroglioma. [J]. Journal of Chongqing Medical University 34(6):725-727(2009)
[1]郭川,唐文渊,钟东,晏怡,姚声涛,刘子杰.CAPE对神经胶质瘤生长抑制作用研究[J].重庆医科大学学报,2009,34(06):725-727. DOI：

GUO Chuan, et al. Effects of caffeic acid phenethyl ester in wnt/β-catenin signaling pathway on human neuroglioma. [J]. Journal of Chongqing Medical University 34(6):725-727(2009) DOI：

摘要

目的:探讨咖啡酸苯乙酯（Caffeic acid phenethyl ester

CAPE）在人神经胶质瘤中的治疗作用。方法:建立裸鼠胶质瘤模型

观察CAPE在体内对肿瘤的影响。运用实时荧光定量PCR、Westernblotting检测CAPE对胶质瘤细胞株U251异常Wnt/β-catenin通路及靶基因c-myc的影响。结果:通过对荷瘤鼠模型的观察

发现口服CAPE可以抑制神经胶质瘤的生长。CAPE可以抑制β-catenin基因mRNA及蛋白的表达

下游靶基因c-myc的mRNA及蛋白表达也相应降低。结论:CAPE可以抑制神经胶质瘤异常Wnt/β-catenin通路中β-catenin基因及c-myc基因的表达

对神经胶质瘤的生长有抑制作用。

Abstract

Objective:The therapic effect of caffeic acid phenethyl ester(CAPE) in neuroglioma was to be investigated in this article.Methods:Athymic mouse model was constructed for therapic observation when tumor was treated by CAPE in vivo.Then Real-time PCR was employed to detected the expressing level of c-myc and β-catenin genes in Wnt/β-catenin signaling pathway when U251 cells were treated by CAPE.Results:CAPE could inhibit the growth of neuroglioma in athymic mouse through drug oral application.The mRNA and protein expression of β-catenin were inhibited.Furthermore

c-myc gene

which was the downstream ofβ-catenin gene

was also down-regulated after the drug treatment.Conclusion:The expressing level of β-catenin and c-myc genes were down-regulated after CAPE treatment

by which the growth of neuroglioma could be inhibited.

关键词

β-catenin咖啡酸苯乙酯神经胶质瘤

Keywords

β-cateninCaffeic acid phenethyl ester(CAPE)neuroglioma

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