The effect of cilostazol on erectile function in diabetic rat model

DOU Hong-zhen; et al

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The effect of cilostazol on erectile function in diabetic rat model

更新时间：2024-01-17

- The effect of cilostazol on erectile function in diabetic rat model
- Journal of Chongqing Medical University Vol. 34, Issue 6, Pages: 721-724(2009)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆市神经病学重点实验室
  3. 重庆医科大学基础医学院生理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R698.1;R587.1
- Published：2009，
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[1]窦红珍,肖明朝,苟欣,李国秧,李静.西洛他唑对糖尿病模型大鼠勃起功能的影响[J].重庆医科大学学报,2009,34(06):721-724.

DOU Hong-zhen, et al. The effect of cilostazol on erectile function in diabetic rat model. [J]. Journal of Chongqing Medical University 34(6):721-724(2009)
[1]窦红珍,肖明朝,苟欣,李国秧,李静.西洛他唑对糖尿病模型大鼠勃起功能的影响[J].重庆医科大学学报,2009,34(06):721-724. DOI：

DOU Hong-zhen, et al. The effect of cilostazol on erectile function in diabetic rat model. [J]. Journal of Chongqing Medical University 34(6):721-724(2009) DOI：

摘要

目的:探讨西洛他唑对糖尿病模型大鼠勃起功能的影响。方法:50只SD雄性大鼠腹腔注射链脲佐菌素建立糖尿病动物模型

成模8周后随机分为糖尿病对照组（DM组）和西洛他唑治疗组（CI组）

同时喂养10只大鼠为正常对照组（C组）。各组动物灌服西洛他唑[20mg/（kg·d）]或者NS。灌胃处理8周后用阿朴吗啡（Apomorphine

APO）诱导法观察勃起功能

用电生理方法测定坐骨神经的运动神经传导速度（Motormerve conduction velocity

MNCV）;并取阴茎海绵体组织用比色法检测一氧化氮合酶（Nitricoxidesynthaes

NOS）水平

用TUNEL法观察阴茎海绵体平滑肌细胞凋亡情况。结果:与DM组相比

CI组的勃起功能、MNCV、NOS水平明显改善

凋亡指数显著降低（P<0.05）。结论:西洛他唑对DM大鼠勃起功能的下降具有明显治疗作用。

Abstract

Objective:To investigate the effect of cilostazol on erectile function in diabetic rat model.Methods:Diabetes were induced in 50 male adult sprague-dawley(SD) rats by an intraperitoneal injection of streptozotocin.The DM rats were randomly divided into diabetic group(DM group )and cilostazol therapy group(CI group) 8 weeks after the injection(another 10 normal SD rats as control

C group).The rats in each group were treated with cilostazol20 mg/(kg·d) or NS through a gastric perfusion for 8 weeks.Then the erectile function of all these rats was evaluated by apomorphine.Motor nerve conduction velocity of sciatic nerve(MNCV) was evaluated by electrophysiology method.Their penis tissues were harvested to measure the level of nitric oxide synthase(NOS) by colorimetric method

and the penile cell apoptosis of smooth muscle was analyzed by TUNEL assay.Results:The erectile function

MNCV and NOS level in CI group significantly increased

while the apoptosis ratio significantly decreased(P<0.05)

compared with DM group.Conclusion:Cilostazol has obvious therapeutic effect on the decrease of erectile function in rats with diabetes.

关键词

糖尿病勃起功能凋亡西洛他唑

Keywords

diabetes mellitusErectile functionapoptosisCilostazol

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