Modification of arterialized orthotopic liver transplantation in rats

HUANG De-rong; et al

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Modification of arterialized orthotopic liver transplantation in rats

更新时间：2024-01-17

- Modification of arterialized orthotopic liver transplantation in rats
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1054-1056(2009)
- 作者机构：
  
  重庆医科大学附属第一医院肝胆外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332;R657.3
- Published：2009，
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[1]黄德荣,吴忠均,朱宇.重建肝动脉的大鼠肝移植模型改良的实验研究[J].重庆医科大学学报,2009,34(08):1054-1056.

HUANG De-rong, et al. Modification of arterialized orthotopic liver transplantation in rats. [J]. Journal of Chongqing Medical University 34(8):1054-1056(2009)
[1]黄德荣,吴忠均,朱宇.重建肝动脉的大鼠肝移植模型改良的实验研究[J].重庆医科大学学报,2009,34(08):1054-1056. DOI：

HUANG De-rong, et al. Modification of arterialized orthotopic liver transplantation in rats. [J]. Journal of Chongqing Medical University 34(8):1054-1056(2009) DOI：

摘要

目的:探讨稳定、高效地建立肝动脉重建的大鼠原位肝移植模型的手术方法。方法:参照"双袖套"法

在供肝的灌注、切取、肝上下腔静脉吻合等方面进行改良

供、受体肝总动脉间用改良的支架法吻合重建肝动脉血供。结果:共完成大鼠原位肝移植80例

供体手术时间:（40±3）min

受体手术时间:（50±5）min

无肝期时间:（16±2）min

肝上下腔静脉吻合时间:（6～9）min

肝动脉吻合时间:（2～3）min。术中无受体死亡

48h存活率为96.3%

1周存活率为93.7%

1月存活率为:87.5%。结论:该方法成活率高

稳定性好

是建立肝动脉重建的大鼠原位肝移植模型的理想方法。

Abstract

Objective:To improve the surgical technique to establish the arterialized orthotopic liver transplantion in rat.Methods:On the basis of two-cuff technique of Kamada

we improved the techniques of separaring

perfusing donor liver

the anastomosis of the suprahepatic inferior vena cava

and so on.And used the modified "stent" method to reestablish the hepatic artery.Results:80 cases of operation were completed.The time of donor operation

recipient operation and anhepatic time were(40±3) min

(50±5)min

and(16±2)min

respectively.The time of reestablishing suprahepatic inferior vena cava and hepatic artery were(6~9) min

(2~3) min

respectively.The survival rate at 48 h

1 week and 1 month were 96.3%

93.7%

and 87.5%

respectively.Conclusion:The modified method can enhance the stability and survival rate

which is an ideal method for establishing the arterialized orthotopic liver transplantation model in rat.

关键词

大鼠肝移植动物模型肝动脉重建

Keywords

Liver transplantationRatanimal modelHepatic rearterialization

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Related Institution

Department of Endocrinology，Chongqing Traditional Chinese Medicine Hospital

Department of Endocrinology，The Second Affiliated Hospital of Chongqing Medical University

Department of Dermatology,The First Affiliated Hospital of Chongqing Medical University

Department of Vascular Surgery,The First Affiliated Hospital of Chongqing Medical University

Department of Gynaecology and Obstetrics,University Town Hospital of Chongqing Medical University

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